A1752
Adenosine 5′-monophosphate sodium salt
≥99%, from yeast, powder
Synonym(s):
5′-Adenylic acid, A-5′-P, AMP
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About This Item
Empirical Formula (Hill Notation):
C10H14N5O7P · xNa+ · yH2O
CAS Number:
Molecular Weight:
347.22 (anhydrous free acid basis)
MDL number:
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51
Assay:
≥99%
Biological source:
yeast
Form:
powder
Solubility:
H2O: soluble
Storage temp.:
−20°C
Product Name
Adenosine 5′-monophosphate sodium salt, from yeast, ≥99%
biological source
yeast
Quality Level
assay
≥99%
form
powder
solubility
H2O: soluble
storage temp.
−20°C
SMILES string
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@]((COP(O)(O)=O)([H])O3.C.
Application
Adenosine 5′-monophosphate sodium salt has been used:
- as a component of reactivation medium to reactivate mouse sperm extracted from caudae epididymides for sperm motility studies
- as a substrate in signal amplification by reversible exchange (SABRE) method to develop biocompatible SABRE hyperpolarization
- as a substrate in wheat and Aspergillus niger phytase, assay
- in luciferase assay to monitor intracellular α-synuclein oligomerization in S1S2 cells
- to study its effects on induction of therapeutic hypothermia and neuronal damage in a rat model of cardiac arrest (CA) and resuscitation
Biochem/physiol Actions
Adenosine 5′-monophosphate (5′-AMP) is used to enhance flavor in meat and poultry soups. It is also used as a food additive for specific nutritional purposes. 5′-AMP is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). Along with inosine monophosphate (IMP), AMP mediates the dissociation of skeletal muscle actomyosin to actin and myosin. Therefore, these two factors may be involved in causing the resolution of rigor mortis in muscles.
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Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Alexey S Kiryutin et al.
Magnetic resonance in chemistry : MRC (2021-06-05)
Signal amplification by reversible exchange (SABRE) is a popular method for generating strong signal enhancements in nuclear magnetic resonance (NMR). In SABRE experiments, the source of polarization is provided by the nonthermal spin order of parahydrogen (pH2 , the H2
Yugo Tsuchiya et al.
Bioscience reports, 32(2), 197-213 (2011-08-20)
In adult rat cardiac myocytes adrenaline decreased AMPK (AMP-activated protein kinase) activity with a half-time of approximately 4 min, decreased phosphorylation of AMPK (α-Thr172) and decreased phosphorylation of ACC (acetyl-CoA carboxylase). Inactivation of AMPK by adrenaline was through both α1- and
Jürgen Knapp et al.
Resuscitation, 85(9), 1291-1297 (2014-07-01)
Animal studies and pathophysiological considerations suggest that therapeutic hypothermia after cardiopulmonary resuscitation is the more effective the earlier it is induced. Therefore this study is sought to examine whether pharmacological facilitated hypothermia by administration of 5'-adenosine monophosphate (AMP) is neuroprotective