A1757
6-Azauracil
≥98%, powder
Synonym(s):
6-AU, 1,2,4-Triazine-3,5(2H,4H)-dione, 3,5-Dihydroxy-1,2,4-triazine, 6-Aza-2,4-dihydroxypyrimidine
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About This Item
Empirical Formula (Hill Notation):
C3H3N3O2
CAS Number:
Molecular Weight:
113.07
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
207-318-0
MDL number:
Beilstein/REAXYS Number:
116472
Assay:
≥98%
Form:
powder
Solubility:
1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow-green
Product Name
6-Azauracil, ≥98%
Quality Level
assay
≥98%
form
powder
mp
274-275 °C (lit.)
solubility
1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow-green
SMILES string
O=C1NN=CC(=O)N1
InChI
1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)
InChI key
SSPYSWLZOPCOLO-UHFFFAOYSA-N
Application
6-Azauracil has been used as a transcriptional inhibitor to study its effects on the deletion of termination and polyadenylation protein (Tpa1) and Mag1 on cell viability. It has also been used as an orotidine-5′-monophosphate decarboxylase (OMPdecase) inhibitor in minimal media for determining the OMPdecase activity.
Biochem/physiol Actions
6-Azauracil (6-AU) is a pyrimidine analog of uracil and exhibits antitumor activity. It inhibits the growth of various microorganisms by depleting intracellular guanosine triphosphate (GTP) and uridine triphosphate (UTP) nucleotide pools.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Product Information Sheet
Peter L Freddolino et al.
eLife, 7 (2018-04-06)
Cells adapt to familiar changes in their environment by activating predefined regulatory programs that establish adaptive gene expression states. These hard-wired pathways, however, may be inadequate for adaptation to environments never encountered before. Here, we reveal evidence for an alternative
Kazuko Matsubara et al.
Genes to cells : devoted to molecular & cellular mechanisms, 12(1), 13-33 (2007-01-11)
The core histones are essential components of the nucleosome that act as global negative regulators of DNA-mediated reactions including transcription, DNA replication and DNA repair. Modified residues in the N-terminal tails are well characterized in transcription, but not in DNA
Kostyantyn V Dmytruk et al.
Metabolic engineering, 13(1), 82-88 (2010-11-03)
Currently, the mutant of the flavinogenic yeast Candida famata dep8 isolated by classic mutagenesis and selection is used for industrial riboflavin production. Here we report on construction of a riboflavin overproducing strain of C. famata using a combination of random