I2764
ML-7
≥98% (TLC), myosin light chain kinase inhibitor, powder
Synonym(s):
1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C15H17IN2O2S · HCl
CAS Number:
Molecular Weight:
452.74
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
ML-7, powder
assay
≥98% (TLC)
Quality Level
form
powder
color
white
solubility
ethanol: water (1:1): 10 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
SMILES string
Cl.Ic1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3
InChI
1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChI key
KDDALCDYHZIZMH-UHFFFAOYSA-N
Gene Information
human ... MYLK(4638), MYLK2(85366)
Application
ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.
Biochem/physiol Actions
Selective myosin light chain kinase inhibitor.
Features and Benefits
This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
M Makishima et al.
FEBS letters, 287(1-2), 175-177 (1991-08-05)
Inhibitors of myosin light chain kinase, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9) and 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), induced Nitroblue tetrazolium reducing activity, lysozyme activity and morphological maturation of human monoblastic U937, THP-1 and promyelocytic HL-60 cells, but not of erythroblastic K562 cells. However, three
Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection
Antoine TE and Shukla D
Antiviral Therapy, 19, 15-29 (2014)
Kristopher E Kubow et al.
Scientific reports, 7(1), 14380-14380 (2017-11-01)
Contact guidance-cell polarization by anisotropic substrate features-is integral to numerous physiological processes; however the complexities of its regulation are only beginning to be discovered. In particular, cells polarize to anisotropic features under non-muscle myosin II (MII) inhibition, despite MII ordinarily