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Merck

K2628

Ketotifen fumarate salt

≥99% (TLC), powder, H₁ histamine receptor antagonist

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About This Item

Empirical Formula (Hill Notation):
C19H19NOS · C4H4O4
CAS Number:
34580-14-8
Molecular Weight:
425.50
NACRES:
NA.77
PubChem Substance ID:
24278506
UNSPSC Code:
12352200
EC Number:
252-100-0
MDL number:
MFCD00079394
Form:
powder
Quality level:
100

Key Documents

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Product Name

Ketotifen fumarate salt,

form

powder

Quality Level

100

originator

Novartis

SMILES string

OC(=O)\C=C\C(O)=O.CN1CCC(\CC1)=C2/c3ccccc3CC(=O)c4sccc24

InChI

1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI key

YNQQEYBLVYAWNX-WLHGVMLRSA-N

Gene Information

human ... HRH1(3269), PDE7B(27115)

Related Categories

General description

Ketotifen fumarate salt is an antihistamine drug.

Application

Ketotifen fumarate salt has been used: for mast cell product antagonism, as a positive control in β-hexosaminidase release assay, as mast cell stabilizer to treat pregnant dams added to ad libitum drinking water

Biochem/physiol Actions

H1 histamine receptor antagonist.
Ketotifen fumarate plays a key role in preventing histamine release by blocking the histamine H1 receptors. It interferes with the release of histamine, serotonin and other inflammatory mediators from mast cells. It exhibits with anti-allergic activity, anti-inflammatory effects including mast cell stabilization. It has been widely used for ophthalmic allergic conjunctivitis.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF0279V
WXBD6993V
WXBD5278V
MKCN1809
WXBD2756V

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Tatsuo Sakamoto et al.
European journal of pharmacology, 685(1-3), 180-185 (2012-05-05)
Toluene is a representative airborne occupational and domestic pollutant that causes eye and respiratory tract irritation. We investigated whether a single inhalation of toluene elicits microvascular leakage in the rat airway. We also evaluated the effects of CP-99,994, a tachykinin
Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats
Massaad CA, et al.
Journal of Neuroimmunology, 153(1-2), 171-182 (2004)
Richard T Eastman et al.
Antimicrobial agents and chemotherapy, 57(1), 425-435 (2012-11-07)
Malaria is a deadly infectious disease in many tropical and subtropical countries. Previous efforts to eradicate malaria have failed, largely due to the emergence of drug-resistant parasites, insecticide-resistant mosquitoes and, in particular, the lack of drugs or vaccines to block
William L
Anabolics (2011)
Jeffrey KA
Side Effects of Drugs Annual (2005)
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