P5891
L-Pyroglutamic acid 2-naphthylamide
≥99% (TLC), suitable for ligand binding assays
Synonym(s):
L-Pyroglutamic acid β-naphthylamide, L-Pyrrolidonyl-β-naphthylamide, N1-(2-Naphthyl)-L-pyroglutamic acid, PYR
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About This Item
Empirical Formula (Hill Notation):
C15H14N2O2
CAS Number:
Molecular Weight:
254.28
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
244-809-9
MDL number:
Beilstein/REAXYS Number:
5066652
Product Name
L-Pyroglutamic acid 2-naphthylamide, ≥99% (TLC)
InChI key
BZEPQNMASTUAMY-ZDUSSCGKSA-N
InChI
1S/C15H14N2O2/c18-14-8-7-13(17-14)15(19)16-12-6-5-10-3-1-2-4-11(10)9-12/h1-6,9,13H,7-8H2,(H,16,19)(H,17,18)/t13-/m0/s1
SMILES string
O=C1CC[C@H](N1)C(=O)Nc2ccc3ccccc3c2
assay
≥99% (TLC)
form
powder
technique(s)
ligand binding assay: suitable
color
white to off-white
storage temp.
2-8°C
Quality Level
Application
A substrate for pyroglutamate aminopeptidase. Used for differentiation of Group A streptococci and enterococci from other streptococci.
Biochem/physiol Actions
Pyroglutamic acid is known to participate in the gamma-glutamyl cycle. Recent studies show that a congenital metabolic error was associated with increased pyroglutamic excretion in urine.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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L P Gordon et al.
Journal of clinical microbiology, 25(2), 238-241 (1987-02-01)
The value of the Strepslide kit for the rapid presumptive identification of streptococci directly from blood cultures without prior determination of hemolysis patterns was assessed and compared with that of the Streptex and Phadebact streptococcus kits. Studies involved 94 simulated
Kevin B Laupland et al.
Infectious diseases (London, England), 50(6), 423-428 (2017-12-22)
The epidemiology of Streptococcus anginosus group (SaG) bloodstream infections (BSI) has not been well defined in non-selected populations. The objective of this study was to determine the incidence, risk factors and outcome associated with SaG BSI. Population-based surveillance was conducted
G A Hébert
Journal of clinical microbiology, 28(11), 2425-2431 (1990-11-01)
Reference strains and clinical isolates representing the newly defined species Staphylococcus lugdunensis and Staphylococcus schleiferi were examined with the battery of tests previously recommended (G.A. Hébert, C.G. Crowder, G.A. Hancock, W.R. Jarvis, and C. Thornsberry, J. Clin. Microbiol. 26:1939-1949, 1988)
Takahiro Tougan et al.
Malaria journal, 18(1), 8-8 (2019-01-16)
The erythrocytic stage of Plasmodium falciparum parasites in humans is clinically important, as the parasites at this growth stage causes malarial symptoms. Most of the currently available anti-malarial drugs target this stage, but the emergence and spread of parasites resistant
Alaa Alachkar et al.
Frontiers in pharmacology, 8, 709-709 (2017-10-28)
The involvement of histamine H3 receptors (H3Rs) in memory is well known, and the potential of H3R antagonists in therapeutic management of neuropsychiatric diseases, e.g., Alzheimer disease (AD) is well established. Therefore, the effects of histamine H3 receptor (H3R) antagonist
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