P9405
O-Phospho-L-tyrosine
≥95.0% (HPLC)
Synonym(s):
L-3-(4-Hydroxyphenyl)alanine 4′-phosphate, L-Tyrosine-O-phosphate
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About This Item
Empirical Formula (Hill Notation):
C9H12NO6P
CAS Number:
Molecular Weight:
261.17
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26
Beilstein/REAXYS Number:
3150815
MDL number:
Product Name
O-Phospho-L-tyrosine,
assay
≥95.0% (HPLC)
Quality Level
form
powder
color
white to off-white
mp
225 °C
application(s)
cell analysis
storage temp.
−20°C
SMILES string
N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(O)=O
InChI
1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1
InChI key
DCWXELXMIBXGTH-QMMMGPOBSA-N
Application
O-Phospho-L-tyrosine has been used:
- as a diluent of anti-phosphotyrosine antibody to study sperm capacitation
- as an amino acid standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis
- as an amino acid standard in two-dimensional thin-layer electrophoresis system to analyze phosphoamino acids on the phosphorylated starch phosphorylase (L-SP)
Biochem/physiol Actions
Phosphotyrosine acts as a docking site in protein regulation by stimulating interaction between tyrosine-phosphorylated proteins and phosphotyrosine domains of other proteins.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
Instructions
Julia Petschnigg et al.
Nature methods, 11(5), 585-592 (2014-03-25)
Cell signaling, one of key processes in both normal cellular function and disease, is coordinated by numerous interactions between membrane proteins that change in response to stimuli. We present a split ubiquitin-based method for detection of integral membrane protein-protein interactions
Chi Hoon Park et al.
BMC cancer, 16, 35-35 (2016-01-24)
c-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has been identified as a good candidate for targeted therapy in gastric cancer.
Bidur Paudel et al.
Biology of reproduction, 100(2), 440-454 (2018-09-22)
Mammalian sperm undergo a series of biochemical and physiological changes collectively known as capacitation in order to acquire the ability to fertilize. Although the increase in phosphorylation associated with mouse sperm capacitation is well established, the identity of the proteins