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Merck

PZ0280

CP-456773 sodium salt

≥98% (HPLC), powder, IL-1β secretion inhibitor

Synonym(s):

CRID3, Cytokine release inhibitory drug 3, MCC950, N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt

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About This Item

Empirical Formula (Hill Notation):
C20H23N2NaO5S
CAS Number:
256373-96-3
Molecular Weight:
426.46
UNSPSC Code:
51111800
PubChem Substance ID:
329823808
NACRES:
NA.77

Key Documents

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Product Name

CP-456773 sodium salt, ≥98% (HPLC)

SMILES string

CC(O)(C)C1=COC(S([N-]C(NC2=C(CCC3)C3=CC4=C2CCC4)=O)(=O)=O)=C1.[Na+]

InChI

1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1

InChI key

LFQQNXFKPNZRFT-UHFFFAOYSA-M

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

room temp

Quality Level

100

Application

CP-456773 sodium salt has been used :
  • In in vivo experiments to study the neuroprotective action of ketogenic diet.
  • To study the effect of inhibition of NLRP3 (nod-like receptor protein 3) inflammasome activity on tumor progression in mouse models.
  • To study the cholesterol crystal-mediated IL-1b (interleukin-1b) response in placental explants.

Biochem/physiol Actions

CP-456773 is known to inhibit the release of other proinflammatory cytokines such as IL-1α and IL-18. It is also referred to as MCC950.
CP-456773 sodium salt (CRID3) was found to act as a cytokine release inhibitory drug and inhibitor of the NLRP3 inflammasome. CP-456773 sodium salt inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000347755
0000347755
0000294163
0000294165
0000259152

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Efficacy and pharmacology of the NLRP3 inflammasome inhibitor CP-456,773 (CRID3) in murine models of dermal and pulmonary inflammation.
Primiano M J, et al.
Journal of Immunology, 197(6), 2421-2433 (2016)
Yingze Ye et al.
Frontiers in cellular neuroscience, 13, 553-553 (2020-01-11)
Ischemic stroke is a devastating disease with long-term disability. However, the pathogenesis is unclear and treatments are limited. Meisoindigo, a second-generation derivative of indirubin, has general water solubility and is well-tolerated. Previous studies have shown that meisoindigo reduces inflammation by
Haining Wang et al.
Life sciences, 227, 101-113 (2019-04-20)
NLRP3 inflammasome has been reported associated with some inflammatory and autoimmune diseases. We previously researches showed that interleukin-23 (IL-23) and interleukin-17 (IL-17) aggravates the ischaemic injury of the brain tissue. However, it is poorly understood whether the NLPR3 inflammasome was
Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma.
Chen L, et al.
Cellular and Molecular Life Sciences, 75(11), 2045-2058 (2018)
Placental inflammation in pre?eclampsia by Nod?like receptor protein (NLRP) 3 inflammasome activation in trophoblasts.
St?dle G S, et al.
Clinical and Experimental Immunology, 193(1), 84-94 (2018)
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