A5486
Azoxymethane
13.4 M, ≥98%
Synonym(s):
AOM
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About This Item
Linear Formula:
CH3N=N(→O)CH3
CAS Number:
Molecular Weight:
74.08
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352124
MDL number:
Assay:
≥98%
Form:
liquid
Quality level:
Storage condition:
(Keep container tightly closed in a dry and well-ventilated place.)
InChI key
DGAKHGXRMXWHBX-ONEGZZNKSA-N
SMILES string
C\N=[N+](/C)[O-]
InChI
1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+
assay
≥98%
form
liquid
composition
methylene chloride, ≤1%
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
concentration
13.4 M
color
colorless
Quality Level
bp
97-99 °C (lit.)
density
0.991 g/mL at 25 °C (lit.)
application(s)
genomic analysis
storage temp.
−20°C
General description
Azoxymethane (AOM) is a potent laboratory chemical used to study cancer initiation, progression, and prevention, particularly in the colon. It acts as both a carcinogen, triggering tumor formation, and a gene mutation agent, causing specific alterations in DNA.
Application
Azoxymethane (AOM), a gene mutation agent, may be used with dextran sulfate sodium (DSS) to create cancer models in laboratory animals which can be used to study mechanisms of cancer progression and chemoprevention.
Biochem/physiol Actions
Carcinogen that induces O6-methylguanine adducts in DNA leading to G→A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.
Features and Benefits
Versatile and adaptable for a wide variety of laboratory and research applications.
Other Notes
For additional information on our range of Biochemicals, please complete this form.
It is critical to determine the correct dosage of Azoxymethane for the experimental design to avoid premature death of laboratory animals.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
75.2 °F
flash_point_c
24 °C
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Carlotta Tacconi et al.
Cancer research, 79(16), 4196-4210 (2019-06-27)
Colorectal cancer is a major cause of cancer-related death in Western countries and is associated with increased numbers of lymphatic vessels (LV) and tumor-associated macrophages (TAM). The VEGFC/VEGFR3 pathway is regarded as the principal inducer of lymphangiogenesis and it contributes
Eva Pastille et al.
PLoS pathogens, 13(9), e1006649-e1006649 (2017-09-25)
Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, strongly associated with an increased risk of colorectal cancer development. Parasitic infections caused by helminths have been shown to modulate the host's immune response by releasing immunomodulatory molecules
Sonia Leon-Cabrera et al.
Cancers, 10(9) (2018-09-22)
Signal transducer and activator of transcription 1 (STAT1) is part of the Janus kinase (JAK/STAT) signaling pathway that controls critical events in intestinal immune function related to innate and adaptive immunity. Recent studies have implicated STAT1 in tumor⁻stroma interactions, and
Bianca N Islam et al.
Cancer prevention research (Philadelphia, Pa.), 10(7), 377-388 (2017-05-05)
Intestinal cyclic guanosine monophosphate (cGMP) signaling regulates epithelial homeostasis and has been implicated in the suppression of colitis and colon cancer. In this study, we investigated the cGMP-elevating ability of the phosphodiesterase-5 (PDE5) inhibitor sildenafil to prevent disease in the
Qifan Zhu et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 4779-4782 (2014-10-17)
Stimulator of IFN genes (STING) is a cytoplasmic innate immune sensor for cyclic dinucleotides that also serves a dual role as an adaptor molecule for a number of intracellular DNA receptors. Although STING has important functions in the host defense
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