A9024
α1-Antitrypsin from human plasma
salt-free, lyophilized powder
Synonym(s):
α1-Proteinase inhibitor
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About This Item
biological source
human plasma
Quality Level
assay
≥70% protein basis (biuret)
form
salt-free, lyophilized powder
storage temp.
2-8°C
Gene Information
human ... ELA2(1991), SERPINA1(5265)
Biochem/physiol Actions
1-4 mg will inhibit 1.0 mg of trypsin with activity of approx. 10,000 BAEE units per mg protein. 1-6 mg will inhibit 1.0 mg of α-chymotrypsin with activity of >=40 BTEE units per mg protein.
Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.
Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α1-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α1-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.
Preparation Note
Chromatographically prepared and partially purified.
Disclaimer
Aqueous stock solutions containing 0.01% NaN3 are stable for several months. Solutions can be stored at −80 °C, but should not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of active site methionine residue.
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Related Content
QC Methods
M Wasil et al.
The Biochemical journal, 243(3), 867-870 (1987-05-01)
Thiourea and dimethylthiourea are powerful scavengers of hydroxyl radicals (.OH), and dimethylthiourea has been used to test the involvement of .OH in several animal models of human disease. It is shown that both thiourea and dimethylthiourea are scavengers of HOCl
B Halliwell et al.
FEBS letters, 213(1), 15-17 (1987-03-09)
Ascorbic acid, at physiological concentrations, can scavenge the myeloperoxidase-derived oxidant hypochlorous acid at rates sufficient to protect alpha 1-antiprotease against inactivation by this molecule. The rapid depletion of ascorbic acid at sites of inflammation, as in the inflamed rheumatoid joint
Roy B Lefkowitz et al.
Analytical chemistry, 82(19), 8251-8258 (2010-09-11)
The ability to measure protease activity in the blood is important for the development of future diagnostics and for biomedical research. Presently, protease assays require sample preparation, making them time-consuming, costly, less accurate, and unsuitable for point-of-care (POC) diagnostics. Recently