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Merck

D7909

Dicyclomine hydrochloride

≥99% (TLC), powder

Synonym(s):

2-(Diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate hydrochloride, [1,1-Bicyclohexyl]-1-carboxylic acid 2-(diethylamino)ethyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H35NO2 · HCl
CAS Number:
67-92-5
Molecular Weight:
345.95
NACRES:
NA.77
PubChem Substance ID:
24278385
UNSPSC Code:
41116107
EC Number:
200-671-1
MDL number:
MFCD00079158

Key Documents

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InChI key

GUBNMFJOJGDCEL-UHFFFAOYSA-N

InChI

1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H

SMILES string

CCN(CCOC(C1(C2CCCCC2)CCCCC1)=O)CC.[Cl]

assay

≥99% (TLC)

form

powder

color

off-white

solubility

H2O: 50 mg/mL

Quality Level

200

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

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Biochem/physiol Actions

Competitive muscarinic acetylcholine receptor antagonist.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000476397
0000459460
0000459460
0000476397
0000311404

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Dicyclomine: cause of abnormally decreased gall bladder ejection with sincalide-stimulated hepatobiliary scintigraphy.
Jesse Woodard et al.
Clinical nuclear medicine, 37(1), 82-85 (2011-12-14)
M Eltze et al.
Pulmonary pharmacology, 7(2), 109-120 (1994-04-01)
The inhibition of preganglionic and postganglionic contractions of the rabbit isolated bronchus/trachea by antagonists with selectivity for different muscarinic receptor subtypes was compared with their affinities at M1, M2, M3 and M4 receptors. Neither M1/M3 receptor-unselective antagonists (atropine, hexahydro-siladifenidol, thiazinamium
Chun-Hui Jin et al.
Journal of neuroscience research, 87(16), 3658-3670 (2009-06-18)
Natural flavonoids ameliorate amyloid-beta peptide (Abeta)-induced neurotoxicity. We examined whether the fustin flavonoid affects Abeta-induced learning impairment in mice. Repeated treatment with fustin significantly attenuated Abeta (1-42)-induced conditioned fear and passive avoidance behaviors. This effect was comparable to that of
K-W Lee et al.
Neuroscience, 153(4), 1235-1244 (2008-05-06)
Muscarinic acetylcholine receptors (M1-M5) regulate many key functions of the CNS and peripheral nervous system. In the present study, the role of M1 muscarinic receptors (M1R) in the psychomotor stimulant and sensitizing properties of methamphetamine (METH) is investigated using molecular
Andrea M Robinson et al.
Journal of psychopharmacology (Oxford, England), 26(8), 1143-1150 (2011-09-06)
The cholinergic system is known to be necessary for normal attentional processing. However, the receptors and mechanisms mediating the effects of acetylcholine on attention remain unclear. Previous work in our laboratory suggested that cholinergic muscarinic receptors are critical for maintaining
View All Related Papers

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