M5693
MEDICA 16
powder, ≥97% (HPLC)
Synonym(s):
3,3,14,14-Tetramethylhexadecanedioic acid
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C20H38O4
CAS Number:
Molecular Weight:
342.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C20H38O4/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24/h5-16H2,1-4H3,(H,21,22)(H,23,24)
SMILES string
CC(C)(CCCCCCCCCCC(C)(C)CC(O)=O)CC(O)=O
InChI key
HYSMCRNFENOHJH-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
color
white to beige
mp
154-159 °C
solubility
DMSO: 10 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Related Categories
Biochem/physiol Actions
MEDICA 16 is an ATP-citrate lyase inhibitor and potent triacylglycerol-lowering agent.
MEDICA 16 is an ATP-citrate lyase inhibitor and potent triacylglycerol-lowering agent. The product is hypolipidemic, antidiabetic, and shows reduced adiposity.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
R Hertz et al.
Biochemical pharmacology, 61(9), 1057-1062 (2001-04-13)
Hepatocyte nuclear factor-4alpha (HNF-4alpha) modulates the expression of liver-specific genes that control the production (e.g. apolipoprotein [apo] A-I and apo B) and clearance (e.g. apo C-III) of plasma lipoproteins. We reported that the CoA thioesters of amphipathic carboxylic hypolipidemic drugs
N Mayorek et al.
Diabetes, 46(12), 1958-1964 (1997-12-10)
Beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) consists of a nonmetabolizable long-chain fatty acid designed to probe the effect exerted by fatty acids on insulin sensitivity. The effect of MEDICA 16 was evaluated in insulin-resistant Zucker (fa/fa) rats in terms of liver
O Hermesh et al.
Biochimica et biophysica acta, 1457(3), 166-174 (2000-04-25)
Calcium-dependent uncoupling of liver mitochondrial oxidative phosphorylation by a non-metabolizable long chain fatty acyl analogue was compared with uncoupling induced by in vivo thyroid hormone treatment. beta,beta'-Methyl-substituted hexadecane alpha, omega-dioic acid (Medica 16) is reported here to induce a saturable
R G Elkin et al.
British poultry science, 33(3), 677-681 (1992-07-01)
1. beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16), an inhibitor of hepatic cholesterogenesis and lipogenesis in rats, was orally administered to 24-week-old White Leghorn hens for a period of 16 d. Hens were fed maize-soya-bean meal diets containing 0, 1.5, or
J C Russell et al.
Diabetes, 47(5), 770-778 (1998-05-20)
The JCR:LA-cp rat develops an extreme obese/insulin-resistant syndrome such that by 12 weeks of age, there is no longer any insulin-mediated glucose turnover. At 4 weeks of age, obese and lean rats have essentially identical basal and insulin-mediated glucose uptake
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service