P3076
Platelet-Derived Growth Factor-AA human
PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
PDGF−AA
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About This Item
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥98% (SDS-PAGE and HPLC)
Form:
lyophilized powder
Mol wt:
28.5 kDa (containing 250 amino acid residues)
Impurities:
<1 EU/μg
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
quality
endotoxin tested
mol wt
28.5 kDa (containing 250 amino acid residues)
packaging
pkg of 10 μg, pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
<1 EU/μg
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... PDGFRA(5154)
potency
≤1.0-3.0 ng/mL ED50
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General description
Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors.
Biochem/physiol Actions
Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.
Physical form
Sterile-filtered through a 0.2 μm filter. Lyophilized with 10 mM acetic acid.
Analysis Note
The biological activity is measured by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells.
Other Notes
Homodimer of the A chain of human PDGF.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Role of platelet-derived growth factors in physiology and medicine.
Andrae J, et al.
Genes & Development, 22.10, 1276-1312 (2008)
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Kohannim O, et al.
Case Reports in Genetics, 2011 (2011)
Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non?small cell lung carcinomas.
Shikada Y, et al.
Cancer Research, 65.16, 7241-7248 (2005)
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