P4670
Propafenone hydrochloride
Synonym(s):
1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C21H27NO3 · HCl
CAS Number:
Molecular Weight:
377.90
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
251-867-9
MDL number:
InChI
1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
InChI key
XWIHRGFIPXWGEF-UHFFFAOYSA-N
SMILES string
Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2
form
powder
originator
Abbott
storage temp.
2-8°C
Quality Level
Gene Information
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Application
Propafenone hydrochloride has been used in the isolation of cardiomyocytes.
Biochem/physiol Actions
Blocks hKv1.5 and ATP-sensitive K+ channels; class 1C antiarrhythmic agent that is also an antagonist at β adrenergic receptors.
Features and Benefits
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
Propafenone hydrochloride is a calcium antagonist. It functions as a Na+ and K+ channel blocker. It might be used to treat patients with systemic hypertension. Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver. Propafenone hydrochloride is used to treat ventricular arrhythmias.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Rate control vs rhythm control in patients with nonvalvular persistent atrial fibrillation: the results of the Polish How to Treat Chronic Atrial Fibrillation (HOT CAFE) Study
Opolski G, et al.
Chest, 126(2), 476-486 (2004)
Propafenone hepatotoxicity: report of a new case and review of the literature
Younan LB, et al.
Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association, 19(5), 235-235 (2013)
Alexander Burashnikov et al.
The Journal of pharmacology and experimental therapeutics, 340(1), 161-168 (2011-10-19)
Ranolazine has been shown to produce atrial-selective depression of sodium channel-dependent parameters and suppress atrial fibrillation (AF) in a variety of experimental models. The present study contrasts the effects of ranolazine and those of a clinically used anti-AF class IC
Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes
Christe G, et al.
European Journal of Pharmacology, 373(2-3), 223-232 (1999)
Lori D Bash et al.
Cardiovascular drugs and therapy, 26(2), 167-179 (2012-03-16)
Rate and rhythm control are two well established treatment objectives for atrial fibrillation (AF) patients. While symptom reduction is a primary treatment goal, therapeutic practice related to cardioversion varies by region and patient, with several precautions associated with the use
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