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P5660

3-sn-Phosphatidyl-L-serine sodium salt from bovine brain

Name: 3-<I>sn</I>-Phosphatidyl-<SC>L</SC>-serine sodium salt from bovine brain
Brand: SIGMA

≥95% (TLC), Procoagulant and Hemostatic regulator, powder

Synonym(s):

1,2-Diacyl-sn-glycero-3-phospho-L-serine, L-α-Phosphatidyl-L-serine sodium salt

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About This Item

UNSPSC Code:

12352200

PubChem Substance ID:

24898688

NACRES:

NA.77

MDL number:

MFCD00077390

Assay:

≥95% (TLC)

Form:

powder

Quality level:

200

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Properties

Product Name

3-sn-Phosphatidyl-L-serine sodium salt from bovine brain, ≥95% (TLC)

Quality Level

200

assay

≥95% (TLC)

form

powder

storage temp.

−20°C

SMILES string

[Na+].CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C([O-])=O)OC(=O)CCCCCCCCCCCCCCCCC

InChI

1S/C42H82NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h38-39H,3-37,43H2,1-2H3,(H,46,47)(H,48,49);/q;+1/p-1/t38-,39+;/m1./s1

InChI key

SJRBMGBLPUBGJL-MBAWARMDSA-M

Description

General description

Phosphatidylserine is an anionic phospholipid, which is found on the plasma membrane. Exposure of phosphatidylserine on the surface of plasma membrane stimulates the removal of apoptotic and red blood cells. It regulates the production of thrombin and maintains hemostasis.

Application

3-sn-Phosphatidyl-L-serine sodium salt from bovine brain has been used as a glycosylphosphatidylinositol (GPI)-anchor control.

Biochem/physiol Actions

A slowly metabolized structural phospholipid found mainly in gray matter.

Preparation Note

Washed with EDTA and converted to a sodium salt.

Disclaimer

Solutions exposed to room temperature will decompose about 0.5% per day.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression

Fadeel B, et al.

Biochemical and Biophysical Research Communications, 266(2), 504-511 (1999)

The role of phosphatidylserine in recognition and removal of erythrocytes.

Kuypers FD

Cellular and molecular biology (Noisy-le-Grand, France), 50(2), 147-158 (2004)

Exposure of platelet membrane phosphatidylserine regulates blood coagulation

Lentz BR

Progress in Lipid Research, 42(5), 423-438 (2003)

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