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Merck

T6069

Thio-TEPA

Synonym(s):

N,N′,N″-Triethylenethiophosphoramide, Thio-Tep, Thiofozil, Thiotef, Tio-tef, Tiofosfamid, Tiofosyl, Tiofozil, Tris(aziridinyl)phosphine sulfide

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About This Item

Empirical Formula (Hill Notation):
C6H12N3PS
CAS Number:
52-24-4
Molecular Weight:
189.22
NACRES:
NA.85
PubChem Substance ID:
24900346
UNSPSC Code:
51102829
EC Number:
200-135-7
MDL number:
MFCD00145452

Key Documents

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InChI key

FOCVUCIESVLUNU-UHFFFAOYSA-N

InChI

1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2

SMILES string

S=P(N1CC1)(N2CC2)N3CC3

form

solid

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

color

white

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

Quality Level

200

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Analysis Note

Solubility - freely soluble in water , in chloroform and in ethanol (96%)

Application

A polyfunctional alkylating agent

Biochem/physiol Actions

The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.

General description

Chemical structure: aziridine

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H300,H350

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000340752
0000340752
0000254894
0000239472
0000239472

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Soo Hyeon Bae et al.
Chemico-biological interactions, 205(1), 11-19 (2013-06-20)
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We consider weighted logrank tests for interval censored data when assessment times may depend on treatment, and for each individual, we only use the two assessment times that bracket the event of interest. It is known that treating finite right
Sotirios G Papageorgiou et al.
Hematological oncology, 31(1), 10-17 (2012-05-23)
Central nervous system (CNS) involvement in patients with primary mediastinal large B-cell (PMLBCL) lymphoma is a rare event, occurring in approximately 6% of patients, on the basis of the review of the literature prior to induction of Rituximab. The aim
J Sanz et al.
Bone marrow transplantation, 47(10), 1287-1293 (2012-02-14)
Attempts to optimize outcomes in cord blood transplantation (CBT) by using new conditioning regimens and standardization of cord blood unit selection are warranted. In all, 88 patients (18 children and 70 adults) with hematological malignancy from nine Spanish institutions underwent
B Kasenda et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 23(10), 2670-2675 (2012-04-05)
High-dose chemotherapy followed by autologous stem-cell transplantation (HCT-ASCT) is a promising approach in eligible patients with primary central nervous system lymphoma (PCNSL). We report long-term data of patients who were treated according to HCT-ASCT containing protocols. We analyzed survival and
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