T7313
1-[2-(Trifluoromethyl)phenyl]imidazole
Synonym(s):
TRIM
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About This Item
Empirical Formula (Hill Notation):
C10H7F3N2
CAS Number:
Molecular Weight:
212.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥98% (GC)
form
solid
solubility
DMSO: soluble 30 mg/mL
storage temp.
2-8°C
SMILES string
FC(F)(F)c1ccccc1-n2ccnc2
InChI
1S/C10H7F3N2/c11-10(12,13)8-3-1-2-4-9(8)15-6-5-14-7-15/h1-7H
InChI key
WZBWBNCQUTXYEL-UHFFFAOYSA-N
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
Biochem/physiol Actions
Potent nitric oxide synthase inhibitor.
Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Eva Šatović et al.
Scientific reports, 9(1), 19962-19962 (2019-12-29)
Terminal repeat retrotransposons in miniature (TRIMs) are small non-autonomous LTR retrotransposons consisting of two terminal direct repeats surrounding a short internal domain. The detection and characterization of these elements has been mainly limited to plants. Here we present the first
R L Handy et al.
British journal of pharmacology, 119(2), 423-431 (1996-09-01)
1. The ability of a range of substituted imidazole compounds to inhibit mouse cerebellar neuronal nitric oxide synthase (nNOS), bovine aortic endothelial NOS (eNOS) and inducible NOS (iNOS) from lungs of endotoxin-pretreated rats was investigated. In each case the substrate
Vallo Volke et al.
Behavioural brain research, 140(1-2), 141-147 (2003-03-20)
Various inhibitors of nitric oxide synthase (NOS) have been shown to possess antidepressant- and anxiolytic-like properties in animal models. The aim of this study was to compare the behavioural effects of NOS inhibitor 7-nitroindazole (7-NI) with the more selective neuronal