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Merck

U1006

Uridine 5′-triphosphate trisodium salt solution

HPLC purified, aqueous solution for RNA polymerase transcription

Synonym(s):

UTP

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About This Item

NACRES:
NA.52
PubChem Substance ID:
24900622
UNSPSC Code:
41106305
MDL number:
MFCD00044310
Assay:
≥95 (HPLC)
Biological source:
yeast (Candida Utilis)
Form:
liquid
Storage temp.:
−20°C

Key Documents

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Product Name

Uridine 5′-triphosphate trisodium salt solution, HPLC purified, aqueous solution for RNA polymerase transcription

InChI

1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1

SMILES string

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O

InChI key

MMJGIWFJVDOPJF-LLWADOMFSA-K

biological source

yeast (Candida Utilis)

assay

≥95 (HPLC)

form

liquid

concentration

100 mM in H2O (adjusted to pH 7 with Trizma®
base)

Quality Level

300

Gene Information

human ... P2RY2(5029)
rat ... P2ry2(29597)

technique(s)

cDNA synthesis: suitable

color

colorless

foreign activity

DNase and RNase, none detected

shipped in

dry ice

storage temp.

−20°C

Related Categories

Application

Uridine 5′-triphosphate trisodium salt solution has been used to increase the intracellular Ca2+ levels in rat primary tracheal epithelial cells. It has also been used as a nucleotide substrate to analyze the activity of MutT homologue 1 (MTH1).

Biochem/physiol Actions

P2Y receptor agonist
UTP plays a crucial role in the process of transcription by participating in the synthesis of RNA. It is associated with glycogen synthesis, protein glycosylation, and membrane phospholipid biosynthesis. UTP is involved in the production of ATP, which is essential for metabolic reactions.
Uridine 5′-triphosphate (UTP) is released during nerve injury and acts as an agonist of the purinergic P2Y2 receptors present on the surface of Schwann cells.

Legal Information

Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000494158
0000494158
0000375452
0000375452
SLCN0184

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Aloa Lamarca et al.
PloS one, 9(6), e98998-e98998 (2014-06-07)
In response to peripheral nerve injury, Schwann cells adopt a migratory phenotype and modify the extracellular matrix to make it permissive for cell migration and axonal re-growth. Uridine 5'-triphosphate (UTP) and other nucleotides are released during nerve injury and activate
Uridine metabolism and its role in glucose, lipid, and amino acid homeostasis
Zhang Y, et al.
BioMed Research International, 2020 (2020)
Biochemistry of uridine in plasma
Yamamoto T, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 412(19-20), 1712-1724 (2011)
Anne Hahn et al.
Physiological reports, 5(12) (2017-06-24)
Transport of water and electrolytes in airway epithelia involves chloride-selective ion channels, which are controlled either by cytosolic Ca2+ or by cAMP The contributions of the two pathways to chloride transport differ among vertebrate species. Because rats are becoming more
Ann-Sofie Jemth et al.
Nucleic acids research, 46(20), 10888-10904 (2018-10-12)
Nucleotides in the free pool are more susceptible to nonenzymatic methylation than those protected in the DNA double helix. Methylated nucleotides like O6-methyl-dGTP can be mutagenic and toxic if incorporated into DNA. Removal of methylated nucleotides from the nucleotide pool

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