329207
Dianhydro-D-glucitol
98%
Synonym(s):
1,4:3,6-Dianhydro-D-sorbitol, D-Isosorbide
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About This Item
Empirical Formula (Hill Notation):
C6H10O4
CAS Number:
Molecular Weight:
146.14
UNSPSC Code:
12352201
NACRES:
NA.22
PubChem Substance ID:
EC Number:
211-492-3
Beilstein/REAXYS Number:
80510
MDL number:
Product Name
Dianhydro-D-glucitol, 98%
InChI key
KLDXJTOLSGUMSJ-JGWLITMVSA-N
InChI
1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1
SMILES string
O[C@H]1CO[C@@H]2[C@H](O)CO[C@H]12
assay
98%
form
solid
optical activity
[α]20/D +45.2°, c = 3 in H2O
mp
60-63 °C (lit.)
Quality Level
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Application
Dianhydro-D-glucitol is a greener ingredient widely used as a monomer and building block for a variety of polymers and functional materials, for medical and pharmaceutical applications. It is also used as a fuel or fuel additive.
Applications include:
Applications include:
- Preparation of renewable polyesters for coating applications.
- Synthesis of isosorbide esters such as oligo(isosorbide adipate) (OSA), oligo(isosorbide suberate) (OSS), and isosorbide dihexanoate (SDH) as renewable alternatives to phthalate plasticizers.
- Synthesis of biodegradable porous polyurethane scaffolds for tissue repair and regeneration.
- Synthesis of the aspirin prodrug, isosorbide-2,5-diaspirinate (ISDA).
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Kazunari Okada et al.
ORL; journal for oto-rhino-laryngology and its related specialties, 74(3), 158-163 (2012-05-16)
We used new criteria to elucidate the demographics of acute low-tone sensorineural hearing loss (ALHL) and tested the Chinese medicine Wu-Ling-San as a treatment for ALHL. We reviewed the medical records of patients with ALHL seen at the outpatient clinic
Oligomeric isosorbide esters as alternative renewable resource plasticizers for PVC.
Yin, Bo and Hakkarainen, Minna
Journal of Applied Polymer Science, 119(4), 2400-2407 (2011)
Biodegradable porous polyurethane scaffolds for tissue repair and regeneration.
Gorna, Katarzyna and Gogolewski, Sylwester
Journal of Biomedical Materials Research Part A, 79(1), 128-138 (2006)
Urgent need for WHO's reform to prioritise core functions.
Mohga Kamal-Yanni et al.
Lancet (London, England), 379(9829), 1878-1878 (2012-05-23)
Neal T Wasserman et al.
Veterinary ophthalmology, 16(1), 20-24 (2012-04-20)
To evaluate and compare the effects of oral isosorbide and glycerol on intraocular pressure (IOP), serum osmolality (SOSM), and blood glucose (BG) in normal dogs. Ten normal dogs were administered an oral dose of either isosorbide (1.5 g/kg), glycerol (1.5g/kg)
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