C-051
Caffeine solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
CAS Number:
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
200-659-6
MDL number:
Product Name
Caffeine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
InChI key
RYYVLZVUVIJVGH-UHFFFAOYSA-N
InChI
1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
SMILES string
CN1C(=O)N(C)c2ncn(C)c2C1=O
grade
certified reference material
form
liquid
feature
SNAP-N-SPIKE®, SNAP-N-SHOOT®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
forensics and toxicology
format
single component solution
storage temp.
−20°C
Quality Level
Gene Information
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
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Application
The Certified Reference Material (CRM) in solution can also be used as follows:
- To determine caffeine content in an aqueous solution of green coffee beans by two methods based on Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR) and fluorescence spectrophotometry
- Extraction of caffeine by automated homogeneous liquid-liquid microextraction (A-HLLME) from five different beverage samples for its quantification by high-performance liquid chromatography combined with UV detection
- Simultaneous estimation of caffeine and chlorogenic acids in ground green coffee samples by a UV/Vis spectrometric method
- Multi-residue determination of caffeine and paracetamol by square-wave voltammetry using poly(4-amino-3-hydroxynaphthalene sulfonic acid)-modified glassy carbon electrode (poly(AHNSA)/GCE in coca-cola, pepsi, and tea samples
- Cyclic voltammetric and differential pulse voltammetric based detection and quantitative analysis of paracetamol, tryptophan, and caffeine, both separately and simultaneously, using an electrochemical sensor founded on tin sulfide (SnS)-titanium dioxide (TiO2)-graphene oxide (GO) composite modified glassy carbon electrode
Features and Benefits
- Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
- Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
- Rigorously tested through real-time stability studies to ensure accuracy and shelf life
- Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
- Flame sealed under argon into ampoules for long-term shelf life
- Offered in a convenient, DEA-exempt format to improve laboratory efficiency
General description
This Snap-N-Spike® Reference Solution is suitable for use in LC/MS or GC/MS applications from clinical toxicology to dietary supplement testing.
Caffeine belongs to the class of active alkaloid compounds, mainly found in the leaves, fruits, and seeds of about 63 plant species. Coffee beans are the primary source of caffeine, in addition to tea leaves, chocolates, and energy drinks soft drinks. It is a central nervous system stimulant and acts by increasing alertness and reducing sleep.
Caffeine belongs to the class of active alkaloid compounds, mainly found in the leaves, fruits, and seeds of about 63 plant species. Coffee beans are the primary source of caffeine, in addition to tea leaves, chocolates, and energy drinks soft drinks. It is a central nervous system stimulant and acts by increasing alertness and reducing sleep.
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Storage Class
3 - Flammable liquids
wgk
WGK 1
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Maria Dobrinas et al.
Pharmacogenetics and genomics, 23(5), 286-292 (2013-03-16)
There is a high interindividual variability in cytochrome P4501A2 (CYP1A2) activity and in its inducibility by smoking, only poorly explained by known CYP1A2 polymorphisms. We aimed to study the contribution of other regulatory pathways, including transcription factors and nuclear receptors
Jane V Higdon et al.
Critical reviews in food science and nutrition, 46(2), 101-123 (2006-03-02)
Coffee is a complex mixture of chemicals that provides significant amounts of chlorogenic acid and caffeine. Unfiltered coffee is a significant source of cafestol and kahweol, which are diterpenes that have been implicated in the cholesterol-raising effects of coffee. The
Lisa N Sharwood et al.
BMJ (Clinical research ed.), 346, f1140-f1140 (2013-03-21)
To determine whether there is an association between use of substances that contain caffeine and the risk of crash in long distance commercial vehicle drivers. Case-control study. New South Wales (NSW) and Western Australia (WA), Australia. 530 long distance drivers
Anne M Larson et al.
Hepatology (Baltimore, Md.), 42(6), 1364-1372 (2005-12-01)
Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and outcomes of acetaminophen-induced ALF at 22 tertiary care centers in the United States. Detailed prospective data were gathered on 662 consecutive patients over
Jack E James
Psychosomatic medicine, 66(1), 63-71 (2004-01-30)
This review aims to determine whether, and to what extent, dietary caffeine may be a risk to cardiovascular health. A critical review of the relevant experimental and epidemiologic literature was conducted, with particular reference to studies of caffeine and blood
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