T8656
Thiourea
ACS reagent grade, ≥99.0%
Synonym(s):
Sulfourea, Thiocarbamide
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About This Item
Linear Formula:
NH2CSNH2
CAS Number:
Molecular Weight:
76.12
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
200-543-5
MDL number:
Beilstein/REAXYS Number:
605327
Assay:
≥99.0%
Product Name
Thiourea, ACS reagent, ≥99.0%
grade
ACS reagent
Quality Level
assay
≥99.0%
ign. residue
≤0.1% (as SO4)
loss
≤0.5% loss on drying, 105°C, 2h
mp
170-176 °C (lit.), 174-177 °C
solubility
H2O: passes test
functional group
amine, thiourea
SMILES string
NC(N)=S
InChI
1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
InChI key
UMGDCJDMYOKAJW-UHFFFAOYSA-N
Gene Information
mouse ... Ephx2(13850)
General description
Thiourea is an analogue of urea containing sulphur.
Application
Chaotropic agent; strong denaturant. Increases solubility and recovery of proteins
Thiourea has been used:
- as a component of lysis buffer for liver tissue homogenization
- in 2-D sample buffer for two-dimensional in-gel protein tyrosine phosphatases (PTP) assay
- in rehydration buffer for protein extraction
Biochem/physiol Actions
Thiourea is a free radical scavenger of the peroxide radical. It was shown to inhibit lipid peroxidation and ultraviolet (UV)-induced crosslinking of collagen. Bud dormancy in plants can be inhibited by thiourea which is used as a growth stimulator. It is also known to be used in the treatment of hyperthyroidism.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Effect of copper nanoparticles exposure in the physiology of the common carp (Cyprinus carpio): Biochemical, histological and proteomic approaches
Gupta YR, et al.
Aquaculture and Fisheries, 1(2), 15-23 (2016)
Investigation of protein-tyrosine phosphatases by in-gel assays.
Markova B, et al.
Methods, 35(1), 22-27 (2005)
Mechanism of the reduction of methylene blue by thiourea in aqueous acidic medium
Osunlaja AA
International Journal of ChemTech Research, 4(2), 609-617 (2012)