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Merck

494488

N,N-Dimethylformamide

biotech. grade, ≥99.9%

Synonym(s):

DMF, NSC 5356

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About This Item

Linear Formula:
HCON(CH3)2
CAS Number:
68-12-2
Molecular Weight:
73.09
UNSPSC Code:
12352111
NACRES:
NA.21
PubChem Substance ID:
329757455
EC Number:
200-679-5
Beilstein/REAXYS Number:
605365
MDL number:
MFCD00003284
grade:
biotech. grade
assay:
≥99.9%
application(s):
peptide synthesis
bp:
153 °C (lit.)
vapor pressure:
2.7 mmHg ( 20 °C)

Product Name

N,N-Dimethylformamide, biotech. grade, ≥99.9%

InChI key

ZMXDDKWLCZADIW-UHFFFAOYSA-N

InChI

1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3

SMILES string

[H]C(=O)N(C)C

grade

biotech. grade

vapor density

2.5 (vs air)

vapor pressure

2.7 mmHg ( 20 °C)

assay

≥99.9%

form

liquid

autoignition temp.

833 °F

expl. lim.

15.2 %

impurities

≤0.0005 meq/g Titr. acid
≤0.003 meq/g Titr. base
≤0.005% (water)
<8 ppm Free amines as dimethylamine

evapn. residue

<0.0005%

refractive index

n20/D 1.430 (lit.)

pH

7 (20 °C, 200 g/L)

bp

153 °C (lit.)

mp

−61 °C (lit.)

solubility

water: miscible

density

0.944 g/mL (lit.)

UV absorption

λ: 270 nm Amax: ≤1.0
λ: 275 nm Amax: ≤0.30
λ: 295 nm Amax: ≤0.10
λ: 310 nm Amax: ≤0.05
λ: 340 nm Amax: ≤0.01
λ: 400 nm Amax: ≤0.01

application(s)

peptide synthesis

storage temp.

room temp

Quality Level

200

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Application

N,N-dimethylformamide (DMF) has been used for the preparation of tetraformylcavitand precursor for generating octahedral nanocontainer.
Solvent for many hydrophobic organic compounds.

General description

N,N-Dimethylformamide (DMF) is a polar organic solvent with a wide range of industrial applications. It is a precursor for numerous reactions such as formylation, aminocarbonylation, amination, amidation and cyanation. Along with phosphorus oxychloride, it forms Vilsmeier reagent used in the formylation of reactive aromatic and heteroaromatic substrates. Dielectric relaxation experiments on DMF have been conducted between 238.15K and 338.15K. The thermophysical properties of the molecular interactions between DMF and the ionic liquids, ammonium salts and imidazolium salts have been studied. The characteristics of solute-solvent interactions between ammonium nitrate and DMF have been investigated.
Our biotech solvents offer exceptional quality for reliable RNA extraction, ensuring optimal laboratory performance. With low water content and minimal residue, give clean UV spectra to minimize contamination.
  • High-Quality Biotech Solvents: Designed for optimal laboratory performance with low water content and minimal residues.
  • Ideal for RNA Extraction: Essential for genetic testing and research applications like PCR.
  • Ensures Integrity of Genetic Material: Promotes reliable and reproducible results.
  • Industry Compliant: Suitable for both academic and commercial laboratories, enhancing research efficiency.

Packaging

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Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

135.5 °F - closed cup

flash_point_c

57.5 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
SHBT4450
SHBT0593
SHBT0405
SHBS5813
SHBR7234

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A simple one-pot multicomponent synthesis of an octahedral nanocontainer molecule.
Liu X and Warmuth R.
Nature Protocols, 2(5), 1288-1296 (2007)
Review article on Vilsmeier Haack reaction and its Applications.
Beniwal M and Jain N.
European Journal of Biomedical AND Pharmaceutical sciences, 2(3), 1340-1374 (2015)
N,N-Dimethylformamide: much more than a solvent.
Muzart J.
Tetrahedron, 65(40), 8313-8323 (2009)
The dynamics of liquid formamide, N-methylformamide, N,N-dimethylformamide, and N,N-dimethylacetamide. A dielectric relaxation study.
Barthel J, et al.
Journal of Molecular Liquids, 98, 51-69 (2002)
Volumetric properties of ammonium nitrate in N,N-dimethylformamide.
Vranes M, et al.
The Journal of Chemical Thermodynamics, 54, 245-249 (2012)
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