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Merck

C3647

Z-L-Lys-SBzl hydrochloride

≥98% (TLC), suitable for ligand binding assays

Synonym(s):

N-α-Cbz-L-lysine thiobenzyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C21H26N2O3S · HCl
CAS Number:
69861-89-8
Molecular Weight:
422.97
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24892633
NACRES:
NA.26
MDL number:
MFCD00058089

Product Name

Z-L-Lys-SBzl hydrochloride,

SMILES string

Cl.NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)SCc2ccccc2

InChI key

PNDSXGXPDJRQAV-FYZYNONXSA-N

InChI

1S/C21H26N2O3S.ClH/c22-14-8-7-13-19(20(24)27-16-18-11-5-2-6-12-18)23-21(25)26-15-17-9-3-1-4-10-17;/h1-6,9-12,19H,7-8,13-16,22H2,(H,23,25);1H/t19-;/m0./s1

assay

≥98% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white

storage temp.

−20°C

Quality Level

200

Related Categories

Application

Z-L-Lys-SBzl hydrochloride has been used as a thioesther substrate in photometric assay and as substrate in determining mast cell protease enzyme activity.

Biochem/physiol Actions

N-α-Cbz-L-lysine thiobenzyl ester (Z-L-Lys-SBzl) is used to identify and characterize specific protease/esterase/granzyme activities associated with lymphocyte cytoplasmic granules.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM7968
BCCL8338
BCCL8339
BCCH6401
BCCH8692

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The isolation and purification of a dual specific mast cell-derived protease from parasitised caprine jejunal tissue
Macaldowie CN, et al.
Research in Veterinary Science, 64(1), 17-24 (1998)
The major component of Na-CBZ-L-lysine thiobenzyl ester (BLT)-specific proteases in cytoplasmic granules of murine intraepithelial lymphocytes is granzyme A.
Kato Y, Yokochi T, Sasaki K, et al.
Immunobiol., 196, 465-474 (1997)
B A Williams et al.
Experimental cell research, 233(1), 187-197 (1997-05-25)
The effect of 2-chloroadenosine (2CA), an adenosine receptor agonist, on the activation status of mouse natural killer (NK) cells was determined. Splenic lymphocytes incubated with 2CA exocytosed an NK cell-associated granzyme with N alpha-CBZ-L-lysine thiobenzyl ester (BLT) esterase activity in
Gregory D Rak et al.
PLoS biology, 9(9), e1001151-e1001151 (2011-09-21)
Accumulation of filamentous actin (F-actin) at the immunological synapse (IS) is a prerequisite for the cytotoxic function of natural killer (NK) cells. Subsequent to reorganization of the actin network, lytic granules polarize to the IS where their contents are secreted
Andrea Kocsis et al.
Journal of immunology (Baltimore, Md. : 1950), 185(7), 4169-4178 (2010-09-08)
The complement system, an essential part of the innate immune system, can be activated through three distinct routes: the classical, the alternative, and the lectin pathways. The contribution of individual activation pathways to different biological processes can be assessed by
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