SAB4500072
Anti-p16 INK antibody produced in rabbit
affinity isolated antibody
Synonym(s):
CD2A1, CDK4I, CDKN2, CDKN2A, CDN2
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Anti-p16 INK antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 16 kDa
species reactivity
mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CDKN2A(1029)
Application
Anti-p16 INK, N-Terminal antibody produced in rabbit has been used in western blot analysis.
Biochem/physiol Actions
Cyclin dependent kinase inhibitor 2A (CDKN2A) also known as P16-INK4A, arrests cell cycle progression by inhibiting S-phase and promotes apoptosis. The encoded protein has anti-proliferative biological activity, and is implicated in the retinoblastoma (Rb) protein pathway. P16-INK4A acts as a tumor suppressor and plays a vital role in ageing and cellular senescence. Increased expression of this protein might lead to various types of high grade cancers. P16-INK4A also facilitates cell invasion and angiogenesis. Bronchial lavage P16INK4A promoter methylation might function as a potential biomarker for diagnosis of lung cancer.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Anti-p16 INK Antibody detects endogenous levels of total p16 INK protein.
Cyclin dependent kinase inhibitor 2A (CDKN2A) also known as P16-INK4A, belongs to the Ink4 (inhibitor of CDK4) family of CDK inhibitors. It is encoded by the gene mapped to human chromosome 9p21 within the INK4a / alternate reading frame (ARF) locus. Human P16-INK4A is localized in both nucleus and cytoplasm, and its expression increases with ageing in skin and kidney tissues.
Immunogen
The antiserum was produced against synthesized peptide derived from human p16 INK.
Immunogen Range: 10-59
Immunogen Range: 10-59
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ping Yang et al.
Journal of cellular and molecular medicine, 28(11), e18388-e18388 (2024-05-31)
Atherosclerosis, characterized by the accumulation of lipid plaques on the inner walls of arteries, is the leading cause of heart attack, stroke and severe ischemic injuries. Senescent cells have been found to accumulate within atherosclerotic lesions and contribute to the
Antiproliferative effects of local anesthetics on mesenchymal stem cells: potential implications for tumor spreading and wound healing.
Lucchinetti E, et al.
Anesthesiology, 116(4), 841-856 (2012)
Expression and significance of p53, rb, p21/waf-1, p16/ink-4a, and PTEN tumor suppressors in canine melanoma.
Koenig A, et al.
Veterinary Pathology, 39(4), 458-472 (2002)
Bronchial lavage P 16INK4A gene promoter methylation and lung cancer diagnosis: A meta-analysis.
Yifan D, et al.
Indian Journal of Cancer, e96-e98 (2015)
p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.
Romagosa C, et al.
Oncogene, 30(18), 2087-2097 (2011)
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