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About This Item
Empirical Formula (Hill Notation):
C11H13BrN2O5
CAS Number:
Molecular Weight:
333.14
UNSPSC Code:
51101500
MDL number:
NACRES:
NA.21
Quality Level
assay
≥95%
antibiotic activity spectrum
viruses
mode of action
enzyme | inhibits
shipped in
ambient
storage temp.
2-8°C
SMILES string
O=C(C(/C=C/Br)=CN1[C@H]2C[C@H](O)[C@@H](CO)O2)NC1=O
InChI
1S/C11H13BrN2O5/c12-2-1-6-4-14(11(18)13-10(6)17)9-3-7(16)8(5-15)19-9/h1-2,4,7-9,15-16H,3,5H2,(H,13,17,18)/b2-1+/t7-,8+,9+/m0/s1
InChI key
ODZBBRURCPAEIQ-PIXDULNESA-N
General description
Brivudine is a synthetic nucleoside analogue antibiotic. It has structural similarities to the natural nucleoside deoxyuridine.
Application
Brivudine has bee used: - in the research of pancreatic cancer
Biochem/physiol Actions
Mode of Action: Brivudine blocks the action of DNA polymerases, inhibiting viral replication.
Antimicrobial Spectrum: Active against Varicella zoster virus and Herpes simplex virus
Antimicrobial Spectrum: Active against Varicella zoster virus and Herpes simplex virus
Features and Benefits
High quality antibiotic suitable for mulitple research applications Commonly used in Cell Biology and Biochemical applications
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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Jörg-Christian Heinrich et al.
Journal of cancer research and clinical oncology, 137(9), 1349-1361 (2011-08-13)
Several reports describe the importance of the chaperone HSP27 (HSPB1) in cancer progression, and the demand for drugs that modulate HSPB1-activity is increasing rapidly. We reported earlier that RP101 (Bromovinyldeoxyuridine, BVDU, Brivudine) improves the efficacy of chemotherapy in pancreatic cancer.