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U6750

Uridine 5′-triphosphate trisodium salt hydrate

Name: Uridine 5&#8242;-triphosphate trisodium salt hydrate
Brand: SIGMA

≥93.0% (HPLC), Thyroid hormone

Synonym(s):

UTP Na₃

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₂N₂Na₃O₁₅P₃ · xH₂O

CAS Number:

19817-92-6

Molecular Weight:

550.09 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

24900658

UNSPSC Code:

12352200

EC Number:

243-347-5

MDL number:

MFCD00044310

Beilstein/REAXYS Number:

3585234

Assay:

≥93.0% (HPLC)

Quality level:

200

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Properties

Product Name

Uridine 5′-triphosphate trisodium salt hydrate, Type IV, ≥93.0% (HPLC)

type

Type IV

Quality Level

200

assay

≥93.0% (HPLC)

solubility

H₂O: soluble 25 mg of UTP in 0.5 ml of solvent, clear, colorless

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O

InChI

1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1

InChI key

MMJGIWFJVDOPJF-LLWADOMFSA-K

Description

Application

UTP has been used as a P2 receptor activator to study its effects on proton efflux in MC3T3-E1 and UMR-106 cells. UTP has also been studied in combination with amiloride hydrochloride in nebulizer solutions for treating cystic fibrosis.

Uridine 5′-triphosphate has been used in a study to show that fluoxetine (FLX), mediates its anti-depressive effect by increasing the gliotransmission of adenosine 5′-triphosphate (ATP).

Biochem/physiol Actions

P2Y receptor agonist.

Uridine-5′-Triphosphate (UTP) is a cytosolic nucleotide component of nucleic acids. It serves as a signaling molecule in the extracellular space. Uridine-5′-Triphosphate (UTP) is involved in various pathophysiological responses in the nervous system. UTP also plays a major role in the regeneration process.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

25 mg of Uridine 5′-triphosphate trisodium salt (UTP Na₃) hydrate is soluble in 0.5 ml of water and yields a clear, colorless solution.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Uridine-5?-Triphosphate Partially Blocks Differentiation Signals and Favors a more Repair State in Cultured rat Schwann Cells

Palomo-Guerrero M, et al.

Neuroscience, 372(2), 255-265 (2018)

Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes

Kinoshita M, et al.

EBioMedicine, 372(2), 255-265 (2018)

Intralesional uridine-5?-triphosphate (UTP) treatment induced resistance to Leishmania amazonensis infection by boosting Th 1 immune responses and reactive oxygen species production

Marques-da-Silva C, et al.

Purinergic Signaling, 14(2), 201-211 (2018)

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