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SCT063 BioTracker™ Si-DMA Singlet Oxygen Live Cell Dye

Live cell imaging dye for singlet oxygen (1O2) localized to mitochondria. Singlet oxygen is important in the field of cancer therapy, photodynamic medicine and other skin treatments.

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SCT063
1 mg  
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      Replacement Information
      Description
      Catalogue NumberSCT063
      DescriptionBioTracker™ Si-DMA Singlet Oxygen Live Cell Dye
      OverviewSinglet oxygen (1O2) is one of the reactive oxygen species (ROS). Singlet oxygen is known to be a cause of spots and wrinkles of the skin due to its very strong oxidizing potential. However, the reactivity of singlet oxygen, if controlled, can be used for therapy. In the field of cancer research and therapy, singlet oxygen is being used for photodynamic therapy (PDT), an emerging anticancer treatment using photoirradiation and photosensitizers.

      BioTracker™ Si-DMA Singlet Oxygen Live Cell Dye is a novel far-red fluorescence probe that is composed of silicon-containing rhodamine and anthracene moieties as a chromophore and a singlet oxygen reactive site, respectively. In the presence of singlet oxygen, fluorescence of BioTracker Si-DMA live cell dye increases 17 times due to endoperoxide formation at the anthracene moiety. The dye is highly selective to singlet oxygen, among seven different reactive oxygen species (1O2, O2-, H2O2, HOCL-, RCO-, OH-, NO). Among three different intracellular photosensitizers, BioTracker Si-DMA selectively detects the 1O2 that is generated by 5-aminolevulinic acid-derived protoporphyrin IX, localized in mitochondria. On the other hand, mitochondria-targeted KillerRed and lysosomal porphyrins could not induce fluorescence change in the dye.

      Spectral Properties
      Absorbance: 640 nm
      Emission: 670 nm

      References
      Kim S. et al. Far-Red Fluorescence Probe for Monitoring Singlet Oxygen during Photodyanamic Therapy. J. Am. Chem. Soc., 2014, 136 (33), 11707-11715.
      Alternate Names
      • Live cell imaging probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized
      Applications
      ApplicationLive cell imaging dye for singlet oxygen (1O2) localized to mitochondria. Singlet oxygen is important in the field of cancer therapy, photodynamic medicine and other skin treatments.
      Key Applications
      • Cell Based Assays
      Application NotesLive cell fluorescent imaging
      Biological Information
      ConcentrationPlease refer to lot specific datasheet.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
      Molar Mass: 513.77 g/mol
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore BioTracker Si-DMA Singlet Oxygen Live Cell Dye at 0-5°C, desiccate and protect from light
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      SCT063 04054839736780