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382120 Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem

382120
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Empirical FormulaCAS #
C₁₆H₁₃ClF₃NO₂ 451491-47-7

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382120-25MG
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      Ampoule plast. 25 mg
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      Description
      OverviewA benzamide compound that activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein 300 in a dose-dependent manner (~6-fold of basal HAT activity of recombinant human p300 toward purified HeLa core histones in the presence of 250 µM CTB). SERS spectrum indicates that CTB interacts with p300 preferentially via the amide groups of the α-helix and β-sheets, resulting in altered enzyme conformation, which presumably accounts for the increased enzymatic activity.
      Catalogue Number382120
      Brand Family Calbiochem®
      SynonymsN-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator
      References
      ReferencesMantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.
      Product Information
      CAS number451491-47-7
      FormOff-white solid
      Hill FormulaC₁₆H₁₃ClF₃NO₂
      Chemical formulaC₁₆H₁₃ClF₃NO₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      382120

      Références bibliographiques

      Aperçu de la référence bibliographique
      Mantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-September-2017 JSW
      SynonymsN-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator
      DescriptionA benzamide compound that activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein 300 in a dose-dependent manner (~6-fold of basal HAT activity of recombinant human p300 toward purified HeLa core histones in the presence of 250 µM CTB). SERS spectrum indicates that CTB interacts with p300 preferentially via the amide groups of the α-helix and β-sheets, resulting in altered enzyme conformation, which presumably accounts for the increased enzymatic activity.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number451491-47-7
      Chemical formulaC₁₆H₁₃ClF₃NO₂
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityEthanol (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesMantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.