G2879
Glycine hydrochloride
≥99% (HPLC), NMDA receptors regulator, powder
Synonym(s):
Aminoacetic acid hydrochloride, Glycine HCl, Glycocoll hydrochloride, Aminoacetic acid, Aminoethanoic acid, Glycocoll
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About This Item
Linear Formula:
H2NCH2CO2H · HCl
CAS Number:
Molecular Weight:
111.53
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.32
EC Number:
227-841-8
MDL number:
Product Name
Glycine hydrochloride, ≥99% (HPLC)
Quality Level
assay
≥99% (HPLC)
form
powder
mol wt
111.53
storage condition
(Tightly closed Dry)
concentration
≤100%
technique(s)
immunohistochemistry: suitable
mp
176-180 °C (lit.)
solubility
water: 0.5 g/mL, clear, colorless
storage temp.
room temp
SMILES string
Cl.NCC(O)=O
InChI
1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H
InChI key
IVLXQGJVBGMLRR-UHFFFAOYSA-N
General description
Research area: Neuroscience
Application
Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.
Glycine hydrochloride has been used:
- in the preparation of glycine-HCl buffer
- to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
- to regenerate the sensor to elute the bound C-reactive protein (CRP)
Biochem/physiol Actions
Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia, and reperfusion.Glycine has been studied as a potential treatment for sepsis, arthritis, adult respiratory distress syndrome, and other inflammatory diseases.
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signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
Product Information Sheet
Zipei Feng et al.
Journal of immunology (Baltimore, Md. : 1950), 196(9), 3943-3950 (2016-03-20)
Recent advances in multiplex immunohistochemistry techniques allow for quantitative, spatial identification of multiple immune parameters for enhanced diagnostic and prognostic insight. However, applying such techniques to murine fixed tissues, particularly sensitive epitopes, such as CD4, CD8α, and CD19, has been
M D Wheeler et al.
Cellular and molecular life sciences : CMLS, 56(9-10), 843-856 (2001-02-24)
The mechanism of the immunosuppressive effects of glycine and its pathophysiological applications are discussed in this review. Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chloride channel (GlyR) expressed in postsynaptic membranes.
Glycine
Hall JC
JPEN. Journal of parenteral and enteral nutrition, 22(6), 393-398 (2019)