P9403
poly(A)
Synonym(s):
Polyadenylic acid potassium salt, Poly(A) potassium salt
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About This Item
Form:
powder
Storage temp.:
−20°C
Application
Polyadenylic acid (poly-A) is used to evaluate binding on cationic liposomes doped with non-ionic nucleolipids. Poly-A is used in small molecule mRNA targeted drug development to evaluate the binding of potential therapeutic agents such as the Isoquinoline group of alkaloids.
Preparation Note
Prepared from ADP with polynucleotide phosphorylase
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Prabal Giri et al.
Molecular bioSystems, 6(1), 81-88 (2009-12-22)
The use of small molecules to specifically control important cellular functions through binding to nucleic acids is an area of major current interest at the interface of chemical biology and medicinal chemistry. The polyadenylic acid [poly(A)] tail of mRNA has
Polyadenylic acid binding on cationic liposomes doped with the non-ionic nucleolipid Lauroyl Uridine.
Cuomo F, Ceglie A, Colafemmina G, et al.
Colloids and Surfaces, B: Biointerfaces, 82, 277-282 (2011)
Prabal Giri et al.
Current medicinal chemistry, 16(8), 965-987 (2009-03-12)
The use of small molecules to specifically control important cellular functions is an area of major current interest at the interface of chemical biology and medicinal chemistry. Recognition of ribonucleic acids (RNA) has emerged more recently as a critical event