SML1620
NGI-1
≥95% (HPLC), Asparagine (N)-linked glycoslysation inhibitor, powder
Synonym(s):
5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-benzamide, ML414
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About This Item
Empirical Formula (Hill Notation):
C17H22N4O3S2
CAS Number:
Molecular Weight:
394.51
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
NGI-1, ≥95% (HPLC)
Quality Level
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(N(C)C)c1cc(c(cc1)N3CCCC3)C(=O)Nc2[s]c(cn2)C
InChI key
QPKGRLIYJGBKJL-UHFFFAOYSA-N
Biochem/physiol Actions
NGI-1 (ML414) is an inhibitor of Asparagine (N)-linked glycoslysation.
NGI-1 (ML414) is an inhibitor of Asparagine (N)-linked glycoslysation. NGI-1 inhibits the oligosaccharyltransferase, preventing the attachment to the protein. NGI-1 has been shown to induce senescence in receptor tyrosine kinase dependent tumors.
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Angelyn Larkin et al.
Biochemistry, 50(21), 4411-4426 (2011-04-22)
Asparagine-linked glycosylation involves the sequential assembly of an oligosaccharide onto a polyisoprenyl donor, followed by the en bloc transfer of the glycan to particular asparagine residues within acceptor proteins. These N-linked glycans play a critical role in a wide variety
Danielle Skropeta
Bioorganic & medicinal chemistry, 17(7), 2645-2653 (2009-03-17)
In a series of investigations, N-glycosylation has proven to be a key determinant of enzyme secretion, activity, binding affinity and substrate specificity, enabling a protein to fine-tune its activity. In the majority of cases elimination of all putative N-glycosylation sites
Cecilia Lopez-Sambrooks et al.
Nature chemical biology, 12(12), 1023-1030 (2016-10-25)
Asparagine (N)-linked glycosylation is a protein modification critical for glycoprotein folding, stability, and cellular localization. To identify small molecules that inhibit new targets in this biosynthetic pathway, we initiated a cell-based high-throughput screen and lead-compound-optimization campaign that delivered a cell-permeable