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Merck

D2950000

Disulfiram

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Tetraethylthiuram disulfide, Bis(diethylthiocarbamoyl) disulfide, Bis(diethylthiocarbamyl) disulfide, Disulfiram, TETD

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About This Item

Linear Formula:
(C2H5)2NCSS2CSN(C2H5)2
CAS Number:
97-77-8
Molecular Weight:
296.54
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329798762
EC Number:
202-607-8
Beilstein/REAXYS Number:
1712560
MDL number:
MFCD00009048

Key Documents

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InChI key

AUZONCFQVSMFAP-UHFFFAOYSA-N

InChI

1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3

SMILES string

CCN(CC)C(=S)SSC(=S)N(CC)CC

grade

pharmaceutical primary standard

API family

disulfiram

manufacturer/tradename

EDQM

mp

69-71 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... ALDH2(217)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Alcohol dehydrogenase inhibitor.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT RE 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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P Liu et al.
British journal of cancer, 107(9), 1488-1497 (2012-10-04)
Glioblastoma multiforme (GBM) cells are resistant to anticancer drugs. Cancer stem cells (CSCs) are a key mediator of chemoresistance. We have reported that disulfiram (DS), an aldehyde dehydrogenase (ALDH) inhibitor, targets breast CSC-like cells. In this study, the effect of
Henning Krampe et al.
Current pharmaceutical design, 16(19), 2076-2090 (2010-05-21)
Supervised intake of the alcohol deterrent (AD) disulfiram has proven to be an effective adjunct to biopsychosocial alcoholism therapy for more than 60 years. This article summarizes disulfiram literature between 1937 and 2000 and reviews 13 clinical trials of disulfiram
Kirsi Ketola et al.
PloS one, 7(12), e51470-e51470 (2012-12-20)
Current treatment options for castration- and treatment-resistant prostate cancer are limited and novel approaches are desperately needed. Our recent results from a systematic chemical biology sensitivity screen covering most known drugs and drug-like molecules indicated that aldehyde dehydrogenase inhibitor disulfiram
Joanna Triscott et al.
Oncotarget, 3(10), 1112-1123 (2012-10-11)
Glioblastomas (GBM) are associated with high rates of relapse. These brain tumors are often resistant to chemotherapies like temozolomide (TMZ) and there are very few treatment options available to patients. We recently reported that polo-like kinase-1 (PLK1) is associated with
Martin Loss et al.
Transplantation, 95(9), 1134-1141 (2013-02-26)
The majority of pancreases, offered in allocation, are discarded. This pancreas underutilization is not well understood yet. We analyzed the detailed allocation protocols of all Eurotransplant-registered German whole-pancreas donors (2005-2009; n=1758). Outcome measures included donor characteristics, number of refusals per
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