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P178

Pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid) tetrasodium salt hydrate

solid, ≥98% (HPLC)

Synonym(s):

4-[[4-Formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-1,3-benzenedisulfonic acid tetrasodium salt, PPADS tetrasodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):
C14H10N3Na4O12PS2 · xH2O
CAS Number:
192575-19-2
Molecular Weight:
599.31 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
24277733
UNSPSC Code:
12352106
MDL number:
MFCD11046026
Assay:
≥98% (HPLC)
Form:
solid
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Quality Level

100

assay

≥98% (HPLC)

form

solid

color

red to orange

solubility

H2O: >10 mg/mL

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].[Na+].[Na+].Cc1nc(\N=N\c2ccc(cc2S([O-])(=O)=O)S([O-])(=O)=O)c(COP([O-])([O-])=O)c(C=O)c1O

InChI

1S/C14H14N3O12PS2.4Na.H2O/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28;;;;;/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28);;;;;1H2/q;4*+1;/p-4/b17-16+;;;;;

InChI key

JTTDHFFNVGHDLN-YDTRVRFHSA-J

Gene Information

human ... LPAR4(2846), LTB4R(1241), P2RX1(5023), P2RY1(5028), P2RY10(27334), P2RY11(5032), P2RY12(64805), P2RY13(53829), P2RY14(9934), P2RY2(5029), P2RY4(5030), P2RY5(10161), P2RY6(5031), P2RY8(286530)

Biochem/physiol Actions

Non-selective P2 purinoceptor antagonist which blocks responses at both pre- and post-junctional sites.

Features and Benefits

This compound is featured on the P2 Receptors: P2X Ion Channel Family and P2 Receptors: P2Y G-Protein Family pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Light sensitive

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000484462
0000484463
0000484462
0000484463
0000424557

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Marian T Namovic et al.
Current protocols in pharmacology, Chapter 9, Unit 9-Unit 9 (2012-06-12)
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Déborah Lécuyer et al.
Frontiers in immunology, 14, 1270081-1270081 (2023-11-03)
Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood. Here, we report that the purinergic receptor P2X7 and NLRP3 inflammasome
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