SAE0062
Lipodisq®
Styrene:Maleic Anhydride Copolymer 2:1, Pre-hydrolyzed
Synonym(s):
Lipodisq Reagent, Lipodisq Solution
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About This Item
NACRES:
NA.25
UNSPSC Code:
12352200
Quality Level
storage temp.
room temp
General description
Lipodisq nanoparticles are usually made up of styrene maleic acid (SMA) copolymer and phospholipids. It has almost similar structure to that of nanodiscs. Lipodisq nanoparticles are considered as a good membrane mimetic system for the structural studies of membrane proteins.
Application
Lipodisq reagents are novel polymers derived from styrene and maleic acid. Lipodisq polymers are capable of forming nanosized lipid-based discoidal particles capable of incorporating membrane proteins. The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents. Lipodisqs typically have a diameter of 9-10 nm at pH 7.4.
The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents.
Functional pH range: 5.5 - 8.0
The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents.
Functional pH range: 5.5 - 8.0
Biochem/physiol Actions
Lipodisq nanoparticles are considered as a good membrane mimetic system for the structural studies of membrane proteins.
Packaging
100, 500 mg in poly bottle
Legal Information
Lipodisq is a registered trademark of Malvern Cosmeceutics Limited
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Related Content
Characterization of KCNE1 inside lipodisq nanoparticles for EPR spectroscopic studies of membrane proteins
Sahu I D, et al.
The Journal of Physical Chemistry B, 121(21), 5312-5321 (2017)
Characterization of the structure of lipodisq nanoparticles in the presence of KCNE1 by dynamic light scattering and transmission electron microscopy
Zhang R, et al.
Chemistry and Physics of Lipids, 203, 19-23 (2017)
Lina Zhu et al.
PeerJ, 10, e13381-e13381 (2022-05-10)
Smoothened (SMO) protein is a member of the G protein-coupled receptor (GPCR) family that is involved in the Hedgehog (Hh) signaling pathway. It is a putative target for treating various cancers, including medulloblastoma and basal cell carcinoma (BCC). Characterizing membrane