160660
Quinaldic acid
98%
Synonym(s):
2-Quinolinecarboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C10H7NO2
CAS Number:
Molecular Weight:
173.17
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
202-218-3
Beilstein/REAXYS Number:
126322
MDL number:
Assay:
98%
Form:
solid
InChI key
LOAUVZALPPNFOQ-UHFFFAOYSA-N
InChI
1S/C10H7NO2/c12-10(13)9-6-5-7-3-1-2-4-8(7)11-9/h1-6H,(H,12,13)
SMILES string
OC(=O)c1ccc2ccccc2n1
assay
98%
form
solid
Quality Level
functional group
carboxylic acid
Related Categories
General description
Quinaldic acid is also referred as quinoline-2-carboxylic acid. Microwave-assisted preparation of substituted anilides of quinaldic acid has been reported. It inhibits the oxidation of pyruvate, α-ketoglutarate, glutamate and citrate in rat liver mitochondria. Quinaldic acid is a metabolite of tryptophan degradation and inhibits the gluconeogenesis in perfused livers.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Pavel Bobal et al.
Molecules (Basel, Switzerland), 17(2), 1292-1306 (2012-02-02)
In this study a one step method for the preparation of substituted anilides of quinoline-2-carboxylic acid was developed. This efficient innovative approach is based on the direct reaction of an acid or ester with substituted anilines using microwave irradiation. The
N D Priestley et al.
Bioorganic & medicinal chemistry, 4(7), 1135-1147 (1996-07-01)
Specifically 13C-labeled quinoline-2-carboxylate derivatives were synthesized from quinoline and used to study the biosynthesis of thiostrepton in a strain of Streptomyces laurentii. 13C NMR analysis of thiostrepton recovered after feeding methyl (RS)-[11-13C]-4-(1-hydroxyethyl)quinoline-2-carboxylate or methyl [11-13C]-4-acetylquinoline-2-carboxylate showed conclusively that these compounds
K Jhamandas et al.
Brain research, 529(1-2), 185-191 (1990-10-08)
Certain products of tryptophan metabolism interact with excitatory amino acid receptors to produce or protect against excitotoxicity. In this study, the action of several tryptophan metabolites, yielded by the kynurenine pathway, on cortical cholinergic toxicity was evaluated following focal injection
Zhao-Qing Du et al.
Journal of Cancer, 11(15), 4614-4624 (2020-06-04)
Platelet-derived growth receptor α (PDGFRα) is a key factor in many pathophysiological processes. The expression level of PDGFRα is significantly elevated in the early stage of liver development and maintained at a lower level in adult normal livers. In this
S Fetzner et al.
Biological chemistry Hoppe-Seyler, 374(6), 363-376 (1993-06-01)
Serratia marcecens 2CC-1 utilizes quinaldic acid (quinoline 2-carboxylic acid) as sole source of carbon, nitrogen and energy. Growth of strain 2CC-1 on quinaldic acid as well as on nicotinic acid and hypoxanthine was inhibited completely by the molybdate antagonist tungstate
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