207713
1,3-Di-o-tolylguanidine
99%
Synonym(s):
DTG
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About This Item
Linear Formula:
(CH3C6H4NH)2C(=NH)
CAS Number:
Molecular Weight:
239.32
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
202-577-6
MDL number:
Assay:
99%
Form:
solid
InChI key
OPNUROKCUBTKLF-UHFFFAOYSA-N
InChI
1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
SMILES string
Cc1ccccc1NC(=N)Nc2ccccc2C
assay
99%
form
solid
mp
176-178 °C (lit.)
solubility
water: soluble 70 mg/mL at 20 °C
functional group
amine
Quality Level
Gene Information
human ... EBP(10682)
Related Categories
General description
1,3-Di-o-tolylguanidine is a selective σ-receptor agonist. 1,3-Di-o-tolylguanidine is σ site ligand and its interaction with dopamine drugs were studied in Wistar rats and Albino Swiss mice.
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Previous studies demonstrated the effectiveness of selective σ-receptor (σR) agonists [1,3-di-o-tolylguanidine (DTG), PRE-084] as reinforcers in rats trained to self-administer cocaine. Similar to cocaine, these drugs increased nucleus accumbens shell dopamine levels, and effects of DTG, but not PRE-084, on
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