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Merck

710806

18-Hydroxycorticosterone

97% (CP)

Synonym(s):

4-Pregnene-11β,18,21-triol-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C21H30O5
CAS Number:
561-65-9
Molecular Weight:
362.46
UNSPSC Code:
12352211
NACRES:
NA.24
PubChem Substance ID:
329763011
EC Number:
209-221-9
Beilstein/REAXYS Number:
2631066
MDL number:
MFCD00042685
Assay:
97% (CP)
Form:
powder

Key Documents

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InChI

1S/C21H30O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,14-17,19,22-23,25H,2-7,9-11H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

InChI key

HFSXHZZDNDGLQN-ZVIOFETBSA-N

SMILES string

O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(CO)[C@@]3([H])CC[C@]4([H])C(CO)=O)=C1

assay

97% (CP)

form

powder

technique(s)

mass spectrometry (MS): suitable

storage temp.

−20°C

Quality Level

200

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Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.
To best serve customer requests, each order is packaged and shipped on demand approximately 2 weeks after receipt of an order. If you have questions regarding availability and price, please contact the Stable Isotope Customer Service Group at 937-859-1808 (1-800-448-9760 for US & Canada) or email us at isosales@sial.com.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MBBF0914
MBBD5665
MBBD6898
MBBD6117
MBBD1895

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M Honda et al.
Endocrinologia japonica, 29(5), 529-540 (1982-10-01)
In order to systematically analyze the regulation and metabolism of steroid hormones in a case of primary aldosteronism with multiple lesions, including adenoma and nodular hyperplasia of the left adrenal gland, the amounts of 9 steroids (progesterone (P), 11-deoxycorticosterone (DOC)
Chun-Hsueh Wu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 785(2), 317-325 (2003-01-30)
The separation and on-line concentration of corticosterone in mouse blood was achieved by means of capillary electrophoresis/UV absorbance using sodium dodecyl sulfate (SDS) as a surfactant. The procedure involved the use of an on-line sample concentration method by sweeping-micellar electrokinetic
J Palmer et al.
Electrophoresis, 19(16-17), 3045-3051 (1998-12-31)
Separation of endogenous 17- or 18-hydroxylated corticosteroids (of the 21-hydroxylated 4-pregnen series) as charged chelates in capillary electrophoresis with borate as the ligand is demonstrated. Aldosterone, 18-hydroxycorticosterone, 18-hydroxy-11-deoxycorticosterone, cortisone, cortisol, and 11-deoxycortisol are separated and resolved by 400 mM borate
P Vecsei et al.
Clinical chemistry, 28(3), 453-456 (1982-03-01)
For distinguishing primary aldosteronism from essential hypertension, we use simple direct radioimmunoassays for "aldosterone" (aldosterone and other materials that react with the antibody to aldosterone) and "18-hydroxycorticosterone" (similarly) in unprocessed urine. Patients with primary aldosteronism have high values for "aldosterone."
M K Birmingham et al.
Endocrine research, 24(3-4), 595-599 (1999-01-15)
A simple semantic differential test was administered twice daily and urinary hormones measured as described previously . The subjects included the patient and two controls, one of whom experienced premenstrual physical, but not mental, discomfort. The test scores of the
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