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Merck

L1002

L-Leucine methyl ester hydrochloride

98%, for peptide synthesis

Synonym(s):

(S)-2-Amino-4-methylpentanoic acid methyl ester hydrochloride, L-Leu-OMe·HCl

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About This Item

Linear Formula:
(CH3)2CHCH2CH(NH2)COOCH3 · HCl
CAS Number:
7517-19-3
Molecular Weight:
181.66
NACRES:
NA.22
PubChem Substance ID:
24896269
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
231-375-0
MDL number:
MFCD00012494
Beilstein/REAXYS Number:
3595133

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Product Name

L-Leucine methyl ester hydrochloride, 98%

InChI

1S/C7H15NO2.ClH/c1-5(2)4-6(8)7(9)10-3;/h5-6H,4,8H2,1-3H3;1H/t6-;/m0./s1

InChI key

DODCBMODXGJOKD-RGMNGODLSA-N

SMILES string

Cl[H].COC(=O)[C@@H](N)CC(C)C

assay

98%

form

powder or crystals

optical activity

[α]22/D +13°, c = 2 in H2O

reaction suitability

reaction type: solution phase peptide synthesis

color

white

mp

151-153 °C (lit.)

application(s)

peptide synthesis

Quality Level

100

Related Categories

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ9340
MKCZ5766
MKCW9327
MKCV9227
MKCR5249

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Stephanie M Krasnow et al.
Journal of neuroinflammation, 14(1), 133-133 (2017-07-03)
During acute infections and chronic illnesses, the pro-inflammatory cytokine interleukin-1β (IL-1β) acts within the brain to elicit metabolic derangements and sickness behaviors. It is unknown which cells in the brain are the proximal targets for IL-1β with respect to the
Gautam K Gandhi et al.
ASN neuro, 2(2), e00030-e00030 (2010-04-17)
Sensory and cognitive impairments have been documented in diabetic humans and animals, but the pathophysiology of diabetes in the central nervous system is poorly understood. Because a high glucose level disrupts gap junctional communication in various cell types and astrocytes
D R Brown et al.
Nature, 380(6572), 345-347 (1996-03-28)
The prion protein PrPc is a glycoprotein of unknown function normally found in neurons and glia. It is involved in diseases such as bovine spongiform encephalopathy (BSE), scrapie and Creutzfeldt-Jakob disease. PrPSc, an altered isoform of PrPC that is associated
Kenneth W Kross et al.
Acta oto-laryngologica, 127(5), 532-539 (2007-04-25)
Conclusion. Tumour-associated macrophages (TAMs) in head and neck squamous cell carcinomas (HNSCCs) secrete interleukin 6 (IL-6) and monocyte chemotactic protein (MCP-1) that can be down-regulated by L-leucine-methylester (LLME); however, there is no qualitative difference between function of TAMs and tissue
T Kiyomasu et al.
Immunology letters, 69(2), 239-245 (1999-09-11)
Recently, long-term preculture with IL-4 or IL-7 has been reported to induce IFN-gamma-producing ability in naive CD4+ T cells without stimulation via TCR. The mechanism of IFN-gamma-transcription in naive CD4+ T cells precultured with IL-4 was analyzed and compared with
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