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07-892

Anti-phospho-Pyk2/CAKβ/FAK2 (Tyr402) Antibody

Upstate®, from rabbit

Synonym(s):

PTK2B, Proline-rich tyrosine kinase 2, Focal adhesion kinase 2, FADK2, Cell adhesion kinase beta, RAFTK, Calcium-dependent tyrosine kinase, CADTK

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
human, rat
Application:
ICC, WB
Citations:
3
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biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, rat

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable, western blot: suitable

isotype

IgG

NCBI accession no.

NM_004103.3, NM_173174.1, NM_173175.1, NM_173176.1

UniProt accession no.

Q14289

shipped in

dry ice

target post-translational modification

phosphorylation (pTyr402)

Gene Information

human ... PTK2B(2185)

General description

115 kDa

Immunogen

Peptide corresponding to amino acid region encompassing the human and rat phospho-Pyk2/CAKβ/FAK2 (Tyr402).

Application

Immunoblot Analysis: 1:1000 dilutions of this lot detected phospho-Pyk2 (Tyr402) in RIPA lysate of Pyk2 transfected CEF cells
This Anti-phospho-Pyk2/CAKβ/FAK2 (Tyr402) Antibody is validated for use in WB, IC for the detection of phospho-Pyk2/CAKβ/FAK2 (Tyr402).

Biochem/physiol Actions

Pyk2 phosphorylated on tyrosine residue 402

Analysis Note

Routinely evaluated by immunoblot.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M D Schaller et al.
The Journal of biological chemistry, 272(40), 25319-25325 (1997-10-06)
pp125(FAK) and CAKbeta/Pyk2/CadTK/RAFTK are related protein-tyrosine kinases. It is therefore of interest whether CAKbeta shares some of the properties of pp125(FAK). Using recombinant glutathione S-transferase fusion proteins, we show that the C-terminal domains of both proteins bind paxillin in vitro.
Monika Raab et al.
Nature communications, 8, 16001-16001 (2017-07-13)
Lymphocyte function-associated antigen 1 (LFA-1) affinity and avidity changes have been assumed to mediate adhesion to intercellular adhesion molecule-1 for T-cell conjugation to dendritic cells (DC). Although the T-cell receptor (TCR) and LFA-1 can generate intracellular signals, the immune cell

Global Trade Item Number

SKUGTIN
07-89204053252731129