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5.08158

TGF-β

InSolution, ≥99%, 50 mM in DMSO, RI Kinase Inhibitor II, RepSox

Synonym(s):

InSolution TGF-β RI Kinase Inhibitor II, RepSox, RepSox InSolution, E-616452 InSolution, ALK5 Inhibitor II, Transforming Growth Factor-β, Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

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About This Item

Empirical Formula (Hill Notation):
C17H13N5
CAS Number:
446859-33-2
Molecular Weight:
287.32
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD09037561
Assay:
≥99% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
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Quality Level

100

assay

≥99% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage temp.

−70°C

SMILES string

[nH]1ncc(c1c4nc(ccc4)C)c2nc3c(nccc3)cc2

InChI

1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)

InChI key

LBPKYPYHDKKRFS-UHFFFAOYSA-N

General description

A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16 µM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
ALK5
Reversible: yes
Target IC50: 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-&beta

Packaging

Packaged under inert gas

Physical form

A 50 mM (5 mg/348 µl) sterile-filtered solution of TGF-β RI Kinase Inhibitor II, RepSox (Cat. No. 616452) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilution.

Other Notes

Ichida, J. K., et al. 2009. Cell Stem Cell5, 491.
Gellibert, F., et al. 2004. J. Med. Chem.47, 4494.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F

flash_point_c

87 °C

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
5.08158.000104055977242904