32402
Sulfaguanidine
VETRANAL®, analytical standard
Synonym(s):
4-Amino-N-(aminoiminomethyl)benzenesulfonamide, 4-Amino-N-guanylbenzenesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C7H10N4O2S
CAS Number:
Molecular Weight:
214.24
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-345-9
Beilstein/REAXYS Number:
2695326
MDL number:
InChI
1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)
InChI key
BRBKOPJOKNSWSG-UHFFFAOYSA-N
SMILES string
NC(=N)NS(=O)(=O)c1ccc(N)cc1
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
clinical testing
format
neat
Quality Level
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Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sulfaguanidine may be used as an analytical reference standard for the determination of sulfaguanidine in:
- Food samples of animal origin by salting-out supported liquid extraction (SOSLE) and quick, easy, cheap, effective, rugged and safe (QuEChERS) extraction followed by analysis using nanoflow liquid chromatography high resolution mass spectrometry (LC-HRMS).
- Bovine muscle samples by hydrophilic interaction liquid chromatography-electrospray-tandem mass spectrometry (HILIC-ESI-MS/MS) equipped with selected reaction monitoring (SRM) mode of detection.
- Tissues, milk and eggs of food producing animals by ultrasound-assisted extraction (UAE), solid phase extraction (SPE) and LC-MS/MS.
- Beeswax by solid-liquid extraction (SLE), liquid-liquid extraction (LLE), SPE, QuEChERS extraction and ESI-LC-MS/MS with SRM detection.
General description
Chemical structure: sulfonamide
Sulfaguanidine belongs to the sulfonamide class of antibiotics. It can exhibit broad-spectrum inhibition of both gram-positive and gram-negative bacteria.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Determination of sulfonamides in beeswax by liquid chromatography coupled to tandem mass spectrometry.
Mitrowska K and Antczak M
Journal of Chromatography. B, Biomedical Sciences and Applications, 1006, 179-186 (2015)
Determination of sulfonamides in serum by on-line solid-phase extraction coupled to liquid chromatography with photoinduced fluorescence detection.
Arroyo-Manzanares N, et al.
Talanta, 138, 258-262 (2015)
Vimal K Balakrishnan et al.
Journal of chromatography. A, 1131(1-2), 1-10 (2006-08-02)
In recent years, pharmaceutical and personal care products (PPCPs) have been detected in diverse environments (including groundwater, river water, and municipal wastewater). In order to evaluate their environmental impact, PPCPs must first be accurately determined. In this study, we focused
B W Clare et al.
Journal of enzyme inhibition, 16(1), 1-13 (2001-08-11)
A series of compounds has been prepared by reaction of dicyandiamide with alkyl/arylsulfonyl halides as well as arylsulfonylisocyanates to locate a lead for obtaining weakly basic thrombin inhibitors with sulfonyldicyandiamide moieties as the S1 anchoring group. The detected lead was
H Sasaki et al.
Journal of pharmacobio-dynamics, 13(3), 200-205 (1990-03-01)
The enhancing effect of pyrrolidone derivatives on the percutaneous penetration of sulfaguanidine, aminopyrine and sudan III was investigated using in vitro technique and excised rat skin. 1-Methyl (MP), 1-hexyl (HP) and 1-lauryl-2-pyrrolidone (LP) were used as penetration enhancers. Aminopyrine showed
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