56480
N-Hydroxysuccinimide
≥97.0% (T), for peptide synthesis
Synonym(s):
1-Hydroxy-2,5-pyrrolidinedione, HOSu, NHS
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About This Item
Empirical Formula (Hill Notation):
C4H5NO3
CAS Number:
Molecular Weight:
115.09
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
EC Number:
228-001-3
MDL number:
Beilstein/REAXYS Number:
113913
Product Name
N-Hydroxysuccinimide, purum, ≥97.0% (T)
grade
purum
Quality Level
assay
≥97.0% (T)
form
solid
reaction suitability
reaction type: Addition Reactions
mp
95-98 °C
application(s)
peptide synthesis
functional group
imide
SMILES string
ON1C(=O)CCC1=O
InChI
1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2
InChI key
NQTADLQHYWFPDB-UHFFFAOYSA-N
Application
N-Hydroxysuccinimide (NHS) can be used in the following applications:
- To synthesize N-succinimidyl 3-(2-pyridyldithio)-propionate, a heterobifunctional reagent useful for protein-protein conjugation and also to incorporate aliphatic thiols into proteins.
- To synthesize NHS esters of long-chain fatty acids.
- NHS can activate the phosphonic acid monolayers immobilized on titanium surface for binding with proteins.
Other Notes
may contain 1-3% succinic acid and/or succinic anhydride
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signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio) propionate, a new heterobifunctional reagent.
Carlsson J
The Biochemical Journal, 173(3), 723-723 (1978)
Synthesis of long-chain fatty acyl-CoA thioesters using N-hydroxysuccinimide esters.
Blecher M
Methods in Enzymology, 72, 404-408 (1981)
Phosphonic acid monolayers for binding of bioactive molecules to titanium surfaces.
Adden N
Langmuir, 22(19), 8197-8204 (2006)