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N9890

Norfloxacin

Name: Norfloxacin
Brand: SIAL

analytical standard, ≥98% (TLC)

Synonym(s):

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₈FN₃O₃

CAS Number:

70458-96-7

Molecular Weight:

319.33

NACRES:

NA.24

PubChem Substance ID:

329818696

UNSPSC Code:

41116107

EC Number:

274-614-4

MDL number:

MFCD00079532

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Properties

Quality Level

200

grade

analytical standard

agency

EPA 1694

assay

≥98% (TLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCNCC3

InChI

1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)

InChI key

OGJPXUAPXNRGGI-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)
rat ... Gabra1(29705)

Description

General description

Norfloxacin is a broad spectrum antibiotic, which is used against a wide variety of gram positive and gram negative bacteria.

Chemical structure: fluoroquinolone

Application

Norfloxacin may be used as a standard in the determination of norfloxacin in human serum samples using fluorometric spectrophotometry.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Norfloxacin blocks DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase).
Mode of action: inhibits bacterial DNA replication
Antimicrobial spectrum: Gram-negative bacteria; less effective against Gram-positive bacteria

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

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Fluorescence reaction and complexation equilibria between norfloxacin and aluminium (III) ion in chloride medium

Djurdjevic.TP, et al.

Analytica Chimica Acta, 300, 253-259 (1995)

Evaluation of quinolones for use in detection of determinants of acquired quinolone resistance, including the new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6')Ib-cr, in Escherichia coli and Salmonella enterica and determinations of wild-type distributions.

L M Cavaco et al.

Journal of clinical microbiology, 47(9), 2751-2758 (2009-07-03)

Fluoroquinolone resistance in members of the Enterobacteriaceae family is mostly due to mutations in the quinolone resistance-determining regions of the topoisomerase genes. However, transferable genes encoding quinolone resistance have recently been described. The current methods for susceptibility testing are not

Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.

Deepika Sharma et al.

European journal of medicinal chemistry, 44(6), 2347-2353 (2008-10-15)

In the present study, we have synthesized 2-(substituted phenyl)-1H-imidazole (1-12) and (substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanone (13-26) analogues and screened them for their antimicrobial activity against gram positive, gram negative and fungal species. The results of antibacterial study indicated that compounds 15

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