P9672
Probucol
analytical standard
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About This Item
Empirical Formula (Hill Notation):
C31H48O2S2
CAS Number:
Molecular Weight:
516.84
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
245-560-9
MDL number:
grade
analytical standard
Quality Level
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
SMILES string
CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C
InChI
1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3
InChI key
FYPMFJGVHOHGLL-UHFFFAOYSA-N
Gene Information
human ... ABCA1(19), IL1B(3553), IL6(3569), TNF(7124)
General description
Probucol is a diphenolic compound possessing antioxidant and anti-inflammatory properties. It is commercially used as a lipid lowering drug, which helps in reducing the total plasma cholesterol, low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL).
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Enhances selective uptake of HDL-associated cholesteryl esters.
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Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Rong Wu et al.
Digestive diseases and sciences, 58(1), 163-171 (2012-08-11)
We sought to evaluate the effects of probucol on steatohepatitis and associated molecular mechanisms in a rat model of nonalcoholic steatohepatitis (NASH) induced by high-fat diet (HFD). Forty male rats weighing 100-120 g were randomly assigned to the following treatments (n = 10
Ryusuke Takechi et al.
Clinical and experimental pharmacology & physiology, 40(1), 45-52 (2012-11-22)
Dysfunction of the blood-brain barrier (BBB) is an early pathological feature of vascular dementia and Alzheimer's disease (AD) and is triggered by inflammatory stimuli. Probucol is a lipid-lowering agent with potent anti-oxidant properties once commonly used for the treatment of
Guadalupe Gómez et al.
Statistics in medicine, 32(5), 719-738 (2012-08-03)
When comparing two treatment groups in a time-to-event analysis, it is common to use a composite event consisting of two or more distinct outcomes. The goal of this paper is to develop a statistical methodology to derive efficiency guidelines for