B7652

Betamethasone 21-phosphate disodium

Name: Betamethasone 21-phosphate disodium
Brand: SIGMA

≥97%, glucocorticoid steroid, powder

Synonym(s):

Betamethasone disodium phosphate, Betamethasone sodium phosphate

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All Photos(3)

About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₈FNa₂O₈P

CAS Number:

151-73-5

Molecular Weight:

516.40

NACRES:

NA.77

PubChem Substance ID:

24892013

UNSPSC Code:

12352200

EC Number:

205-797-0

MDL number:

MFCD00200361

Product Name

Betamethasone 21-phosphate disodium, ≥97%

InChI key

PLCQGRYPOISRTQ-LWCNAHDDSA-L

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1

SMILES string

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

sterility

non-sterile

assay

≥97%

form

powder

solubility

water: 50 mg/mL, clear to very slightly hazy, faintly yellow

shipped in

ambient

storage temp.

room temp

Quality Level

100

Gene Information

human ... NR3C1(2908)

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Related Categories

Bioactive Small Molecules

Chemistry & Biochemicals

Phosphates

Biochem/physiol Actions

Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis.

General description

Betamethasone is a corticosteroid with anti-inflammatory and immunosuppressive abilities, used especially where water retention is undesirable. It is applied as a topical cream, ointment, lotion or gel to treat itching (e.g. from eczema). Corticosteroid used to stimulate fetal lung maturation and to decrease the incidence and mortality from intracranial hemorrhage in premature infants

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H360FD,H373

pcodes

P202 - P260 - P264 - P280 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B - STOT RE 2

target_organs

Liver,Kidney,Endocrine system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Efficacy results of a 52-week, randomised, double-blind, safety study of a calcipotriol/betamethasone dipropionate two-compound product (Daivobet/Dovobet/Taclonex) in the treatment of psoriasis vulgaris

Kragballe K, et al.

Dermatology (Basel, Switzerland), 213(4), 319-326 (2006)

Therapeutic effect of stealth-type polymeric nanoparticles with encapsulated betamethasone phosphate on experimental autoimmune uveoretinitis.

Tsutomu Sakai et al.

Investigative ophthalmology & visual science, 52(3), 1516-1521 (2010-12-24)

The therapeutic effects of betamethasone phosphate (BP) encapsulated in biocompatible and biodegradable blended nanoparticles of poly(lactic acid) (PLA) homopolymers and PEG-block-PLA copolymers (stealth nanosteroids) were examined in an experimental autoimmune uveoretinitis (EAU) model in Lewis rats. EAU was induced by

Beneficial pharmacological effects of selective glucocorticoid receptor agonist in external eye diseases.

Masatomo Kato et al.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 27(4), 353-360 (2011-05-18)

Glucocorticoids exert their actions via the glucocorticoid receptor through at least 2 intracellular mechanisms, known as transrepression and transactivation. It has been hypothesized that transrepression is the basis of their anti-inflammatory effects, whereas transactivation has been assumed to cause their

Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatory agents.

Tsutomu Ishihara et al.

International journal of pharmaceutics, 385(1-2), 170-175 (2009-10-20)

We have prepared polymeric nanoparticles using a blend of poly(lactic acid) and monomethoxy-polyethyleneglycol(PEG)-polylactide block copolymer along with betamethasone disodium phosphate (BP). Nanoparticles have been screened for anti-inflammatory activity using experimental rat models of inflammation. In the present study, we examined

A stability-indicating reversed-phase high performance liquid chromatography method for simultaneous assay of two corticosteroids and estimation of their related compounds in a pharmaceutical injectable formulation.

Jun Lu et al.

Journal of chromatography. A, 1217(44), 6932-6941 (2010-09-22)

Betamethasone Sodium Phosphate and Betamethasone Acetate are the two corticosteroids active pharmaceutical ingredients (APIs) that are present in the injectable formulation, Celestone Chronodose(®) Injection. It is extremely challenging to develop a Quality Control friendly HPLC method to separate all the

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