C3366
Anti-CXCR5 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-CXC Chemokine Receptor 5
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p)
Citations:
2
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5 μg/mL using human lymph node, B-cell lymphoma
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CXCR5(643)
mouse ... Cxcr5(12145)
rat ... Cxcr5(29363)
Immunogen
synthetic peptide corresponding to the C-terminus of human CXC chemokine receptor 5 (CXCR5), conjugated to KLH. The immunizing peptide has 94% homology with the rat gene and 100% homology with the mouse gene.
Biochem/physiol Actions
CXCR5 is a multi-pass membrane protein expressed in mature B cells. It binds to B-lymphocyte chemoattractant and regulates the migration of B cells. The expression of CXCR5 is important for CD4 T cell-mediated humoral immune responses.
Physical form
Solution in PBS, 0.1% Sodium Azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Through the looking glass: the diverse in vivo activities of chemokines.
S L Kunkel
The Journal of clinical investigation, 104(10), 1333-1334 (1999-11-24)
Nina Chevalier et al.
Journal of immunology (Baltimore, Md. : 1950), 186(10), 5556-5568 (2011-04-08)
High expression of CXCR5 is one of the defining hallmarks of T follicular helper cells (T(FH)), a CD4 Th cell subset that promotes germinal center reactions and the selection and affinity maturation of B cells. CXCR5 is also expressed on