D7815
R(−)-Denopamine
≥98% (HPLC), β1 adrenoceptor agonist, powder
Synonym(s):
(−)-α-(3,4-Dimethoxyphenethylaminomethyl)-4-hydroxybenzylalcohol
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About This Item
Empirical Formula (Hill Notation):
C18H23NO4
CAS Number:
Molecular Weight:
317.38
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
R(−)-Denopamine, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: 10 mg/mL, clear, H2O: insoluble
storage temp.
2-8°C
SMILES string
COc1ccc(CCNC[C@H](O)c2ccc(O)cc2)cc1OC
InChI
1S/C18H23NO4/c1-22-17-8-3-13(11-18(17)23-2)9-10-19-12-16(21)14-4-6-15(20)7-5-14/h3-8,11,16,19-21H,9-10,12H2,1-2H3/t16-/m0/s1
InChI key
VHSBBVZJABQOSG-INIZCTEOSA-N
Gene Information
human ... ADRB1(153)
Application
R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).
Biochem/physiol Actions
Denopamine is a cardiotonic drug.
β1-adrenoceptor agonist.
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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T Bando et al.
Oncology reports, 7(1), 49-52 (1999-12-22)
Cisplatin is a key drug in chemotherapy for lung cancer. It has been reported that intracellular accumulation of cisplatin is an important step as a determinant for resistance to cisplatin, which may be modulated by Na+, K+-ATPase activity. And it
Hidefumi Kaji et al.
Drug metabolism and disposition: the biological fate of chemicals, 33(3), 403-412 (2004-12-21)
Denopamine is one of the oral beta(1)-adrenoceptor-selective partial agonists. Denopamine glucuronide is the most abundant metabolite in human, rat, and dog urine when administered orally. Species differences in denopamine glucuronidation were investigated with liver microsomes obtained from humans and experimental
S Chiba et al.
Journal of autonomic pharmacology, 21(1), 7-13 (2001-06-26)
1. Using the cannula inserting method, vasodilator responses to beta-adrenoceptor agonists (isoprenaline, denopamine and procaterol) were investigated in isolated and perfused rat common carotid arteries. 2. Each beta-adrenoceptor agonist induced a vasodilation in preparations preconstricted by phenylephrine in a dose-related