F6889
Famotidine
histamine receptor antagonist
Synonym(s):
N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine
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About This Item
Empirical Formula (Hill Notation):
C8H15N7O2S3
CAS Number:
Molecular Weight:
337.45
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Quality level:
Product Name
Famotidine,
Quality Level
originator
Johnson & Johnson
SMILES string
N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1
InChI
1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
InChI key
XUFQPHANEAPEMJ-UHFFFAOYSA-N
Gene Information
human ... HRH2(3274)
Application
Famotidine has been used to test its effect on the human ether-a-go-go-related gene (hERG) binding transfected in HEK293 membrane. It has also been used in polycaprolactone based drug delivery studies.
Biochem/physiol Actions
H2 histamine receptor antagonist; anti-ulcer agent
Famotidine is not effective on muscarinic and nicotinic receptors. It competitively inhibits the secretion of gastric acid and elicits mucosal injury protection.
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs
Taha AS, et al.
The New England Journal of Medicine, 334(22), 1435-1439 (1996)
Polycaprolactone thin-film drug delivery systems: empirical and predictive models for device design
Schlesinger E, et al.
Materials Science and Engineering, C, 57, 232-239 (2015)
Famotidine: an update review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied disease
Healther DL, et al.
Drugs, 38(3), 551-590 (2015)