I0879
Inosine 5′-triphosphate trisodium salt
≥95%
Synonym(s):
ITP
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About This Item
Empirical Formula (Hill Notation):
C10H12Na3N4O14P3
CAS Number:
Molecular Weight:
574.11
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Assay:
≥95%
Storage temp.:
−20°C
Quality Level
assay
≥95%
shipped in
dry ice
storage temp.
−20°C
SMILES string
[Na].OC1C(O)C(OC1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n2cnc3C(=O)N=CNc23
InChI
1S/C10H15N4O14P3.Na.H/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20);;
InChI key
RIERCUPIZLBNFQ-UHFFFAOYSA-N
Gene Information
human ... HRAS(3265)
Application
Inosine 5′-triphosphate trisodium salt has been used to investigate its influence on the chromosome aberration rate, the mitotic rate, sister-chromatid exchange (SCE) frequency, the proportion of first (X1), second (X2) and third (X3) division metaphases of human peripheral lymphocytes.
Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. ITP may be used as a substrate to study the specificity and kinetics of nucleoside-5′-triphosphatase and ATPase. ITP is also used to study activation of various ATPases and GTPases.
Biochem/physiol Actions
Inosine 5′-triphosphate (ITP) has the ability to support the initiation of effector system. It can prevent guanosine 5′-triphosphate (GTP) hydrolysis, that is catalysed by transducin (TD). ITP can proficiently induce secretion in permeabilized cells than GTP. Instead of GTP, ITP can be used for the initiation and the elongation steps of reovirus transcription. ITP can also replace GTP in the activation of G-protein.
Preparation Note
Prepared from Bacterial ATP
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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As to the clastogenic-, sister-chromatid exchange inducing-and cytotoxic activity of inosine triphosphate in cultures of human peripheral lymphocytes
Vormittag W and Brannath W
Mutation Research, 476(1), 71-81 (2001)
T Toyo-oka
Circulation research, 49(6), 1350-1355 (1981-12-01)
The contraction of cardiac muscle that has been treated with glycerol requires Ca2+ (pCa 8-5), when MgATP is used as a substrate. In contrast, this preparation contracts, even in the absence of Ca2+ (pCa 8-10), when ATP is replaced by
Initiation of reovirus transcription by inosine 5'-triphosphate and properties of 7-methylinosine-capped, inosine-substituted messenger ribonucleic acids
Morgan M A and Shatkin A J
Biochemistry, 19(26), 5960-5966 (1980)