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N3136

Naltrexone hydrochloride

Name: Naltrexone hydrochloride
Brand: SIGMA

≥99% (HPLC), powder, opioid receptor antagonist

Synonym(s):

Naltrexone HCl

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₃NO₄ · HCl

CAS Number:

16676-29-2

Molecular Weight:

377.86

NACRES:

NA.77

PubChem Substance ID:

24278051

UNSPSC Code:

12352200

EC Number:

240-723-0

MDL number:

MFCD00069324

Beilstein/REAXYS Number:

3580333

Form:

powder

Quality level:

100

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Properties

Product Name

Naltrexone hydrochloride,

form

powder

Quality Level

100

originator

Novartis

storage temp.

2-8°C

SMILES string

Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6

InChI

1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1

InChI key

RHBRMCOKKKZVRY-ITLPAZOVSA-N

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)

Description

Application

Naltrexone hydrochloride has been used:

as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Development and validation of a bioanalytical method for the simultaneous determination of heroin, its main metabolites, naloxone and naltrexone by LC-MS/MS in human plasma samples: Application to a clinical trial of oral administration of a heroin/naloxone formulation.

Raquel Moreno-Vicente et al.

Journal of pharmaceutical and biomedical analysis, 114, 105-112 (2015-06-04)

A bioanalytical method using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated for simultaneous quantification of heroin, its main metabolites and naloxone. In addition, naltrexone was detected qualitatively. This method was used to analyse human plasma samples from

Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A)

Prukop T, et al.

Testing, 14(1), e0209752-e0209752 (2019)

Caenorhabditis elegans show preference for stimulants and potential as a model organism for medications screening

Engleman EA, et al.

Frontiers in Physiology, 9, 7-16 (2018)

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