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P0547

Pentamidine isethionate salt

Name: Pentamidine isethionate salt
Brand: SIGMA

NMDA glutamate receptor antagonist, powder

Synonym(s):

1,5-Bis(p-amidinophenoxy)pentane bis(2-hydroxyethanesulfonate salt), 4,4′-(Pentamethylenedioxy)dibenzamidine bis(2-hydroxyethanesulfonate)

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About This Item

Linear Formula:

CH₂[CH₂CH₂OC₆H₄C(=NH)NH₂]₂·2HOCH₂CH₂SO₃H

CAS Number:

140-64-7

Molecular Weight:

592.68

NACRES:

NA.77

PubChem Substance ID:

24277999

UNSPSC Code:

12352200

EC Number:

205-424-1

MDL number:

MFCD00079213

Form:

powder

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Properties

Product Name

Pentamidine isethionate salt, powder

form

powder

Quality Segment

100

mp

188-194 °C (lit.)

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

originator

Celgene

storage temp.

−20°C

SMILES string

OCCS(O)(=O)=O.OCCS(O)(=O)=O.NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1

InChI

1S/C19H24N4O2.2C2H6O4S/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23;2*3-1-2-7(4,5)6/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);2*3H,1-2H2,(H,4,5,6)

InChI key

YBVNFKZSMZGRAD-UHFFFAOYSA-N

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907), NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Description

Application

Antimicrobial against Pneumocystis carinii.

Pentamidine isethionate salt has been used:

as a positive control for anti-leishmanial, anti-plasmodial and cytotoxic assays
as a prototypical compound to analyse the inhibitor effect on human ether-a-go-go-related gene (HERG) K⁺ channel trafficking
as an anti-leishmanial agent in promastigotes

Biochem/physiol Actions

Neuroprotective; inhibits constitutive nitric oxide synthase in the brain; NMDA glutamate receptor antagonist.

Pentamidine isethionate is used as a second line drug for leishmaniasis.

Features and Benefits

This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H315,H317,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

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